NCT05056701: PRECEDE

Prediction of Chronic Kidney Disease Following Pre-eclampsia: Diagnosis and Early Care

Recruiting now NA Last updated 4 September 2024

What this trial tests

NA trial testing annual follow-up during 10 years in Preeclampsia in 400 participants. Currently enrolling.

Timeline

30 May 2022

Primary endpoint
30 May 2037

30 May 2037

Quick facts

Lead sponsor	Centre Hospitalier le Mans
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	400
Start date	30 May 2022
Primary completion	30 May 2037
Estimated completion	30 May 2037
Sites	2 locations across France

Drugs / interventions tested

• annual follow-up during 10 years

Conditions studied

• Preeclampsia — all drugs for Preeclampsia →

Sponsor

Centre Hospitalier le Mans

Who can join

18 and older, female only, with Preeclampsia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Pre-eclampsia (PE) is a pregnancy-associated syndrome of variable severity, classically defined by the combination of hypertension and proteinuria in a previously non-hypertensive or proteinuric patient. These symptoms normally resolve within 2-3 months after delivery regardless of the severity of the pre-eclampsia.

Regardless of its definition, preeclampsia is associated with an increased risk of obstetric events and, for the mother, an increased risk of developing chronic kidney disease (CKD), hypertension, diabetes and cardiovascular disease in the broad sense.

The relationship between preeclampsia and Chronic Kidney Disease is, however, complex and not fully understood.

Investigator proposes an interventional study to identify the diagnosis of Chronic Kidney Disease in patients who have developed an episode of Preeclampsia.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Recurrence of preeclampsia is common, even during rigorously controlled multidisciplinary follow-up: a pilot experience.
   De Marco O, Ruotolo C, Njanjo L, Mariani C, et al · · 2025 · cited 1× · PMID 40226375 · DOI 10.1093/ckj/sfaf070