NCT05054361 (MAIT-DT1) is a clinical trial of MAIT cells analysis in Type1diabetes, sponsored by Institut National de la Santé Et de la Recherche Médicale, France.

Who is sponsoring NCT05054361?

NCT05054361 is sponsored by Institut National de la Santé Et de la Recherche Médicale, France.

What drugs are being tested in NCT05054361?

Interventions in NCT05054361: MAIT cells analysis, MAIT cytokines production analysis, Lactulose/Mannitol Test, UGI Endoscopy, Coxsackie virus B infection status, Coxsackie virus B infection status.

What condition does NCT05054361 study?

NCT05054361 studies Type1diabetes.

Is NCT05054361 still recruiting?

NCT05054361 is currently recruiting now. Last updated 13 April 2026.

Last reviewed 2026-04-13 · How we verify

NCT05054361: MAIT-DT1

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Crosstalk Between Mucosal-Associated Invariant T (MAIT) Cells and the Gut Microbiota and Mucosa in the Development of Type 1 Diabetes in Children

Recruiting now Last updated 13 April 2026

What this trial tests

trial testing MAIT cells analysis in Type1diabetes in 180 participants. Currently enrolling.

Timeline

1 January 2022

Primary endpoint
11 August 2026

14 August 2027

Quick facts

Lead sponsor	Institut National de la Santé Et de la Recherche Médicale, France
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	180
Start date	1 January 2022
Primary completion	11 August 2026
Estimated completion	14 August 2027
Sites	2 locations across France

Drugs / interventions tested

MAIT cells analysis
MAIT cytokines production analysis
Lactulose/Mannitol Test
UGI Endoscopy
Coxsackie virus B infection status
Coxsackie virus B infection status

Conditions studied

Type1diabetes — all drugs for Type1diabetes →

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France — full company profile →

Who can join

Adults 12 Months to 15, any sex, with Type1diabetes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To investigate in a prospective way changes in Mucosal-Associated Invariant T (MAIT) cells frequency, phenotype and function in link with the gut microbiota, gut integrity and the presence of Coxsackie virus B in two cohorts of pediatric patients: patients with a high genetic risk of type 1 diabetes and pediatric patients with recently diagnosed T1D by comparison with control subjects Tasks: 1. To measure blood MAIT cells frequency, phenotype and function in the three cohorts 2. To analyze gut microbiota and the presence of Coxsackie B enterovirus (CVB) and their impact on MAIT cell function 3. To evaluate gut integrity and analyze the gut mucosa 4. To integrate all the data obtained with T1D development and evolution

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

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Other Institut National de la Santé Et de la Recherche Médicale, France trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05054361 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Institut National de la Santé Et de la Recherche Médicale, France
Last refreshed: 13 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05054361.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing