NCT05041270 is a NA clinical trial of normal saline in Lower Limb Surgeries, sponsored by Zagazig University.

Who is sponsoring NCT05041270?

NCT05041270 is sponsored by Zagazig University.

What drugs are being tested in NCT05041270?

Interventions in NCT05041270: normal saline, Dexmedetomidine, Nalbuphine.

What condition does NCT05041270 study?

NCT05041270 studies Lower Limb Surgeries.

Is NCT05041270 still recruiting?

NCT05041270 is currently completed. Last updated 12 May 2023.

Last reviewed 2023-05-12 · How we verify

NCT05041270

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Epidural Nalbuphine Versus Dexmedetomidine as Adjuvants to Bupivacaine in Lower Limb Surgeries

Completed NA Last updated 12 May 2023

What this trial tests

NA trial testing normal saline in Lower Limb Surgeries in 23 participants. Completed in 15 May 2022.

Timeline

1 October 2021

Primary endpoint
30 April 2022

15 May 2022

Quick facts

Lead sponsor	Zagazig University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	23
Start date	1 October 2021
Primary completion	30 April 2022
Estimated completion	15 May 2022
Sites	1 location across Egypt

Drugs / interventions tested

normal saline
Dexmedetomidine (dexmedetomidine) — full drug profile →
Nalbuphine — full drug profile →

Conditions studied

Lower Limb Surgeries — all drugs for Lower Limb Surgeries →

Sponsor

Zagazig University

Who can join

Adults 21 to 60, any sex, with Lower Limb Surgeries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Combined spinal epidural anesthesia (CSE) with bupivacaine alone is not sufficient to cover pain sequel during lower limb surgeries. Previous studies used addition of either Nalbuphine or dexmedetomidine to bupivacaine in epidural anesthesia giving a good result in pain control. In this study the investigators will evaluate and compare the addition of either Nalbuphine or dexmedetomidine to bupivacaine in epidural anesthesia to evaluate the analgesic efficacy of either drug.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Epidural nalbuphine versus dexmedetomidine as adjuvants to bupivacaine in lower limb orthopedic surgeries for postoperative analgesia: a randomized controlled trial.
Farmawy MSE, Mowafy SMS, Wahdan RA. · · 2023 · cited 4× · PMID 38057695 · DOI 10.1186/s12871-023-02348-x

Verify or expand the search:

Other trials of normal saline

Trials testing the same drug.

NCT05727618 — The Effect of Pituitrin on the Patients With Pulmonary Hypertension Undergoing Cardiac Surgery · NA · suspended
NCT07294755 — The Impact of Intrapleural Block on Postoperative Pain Caused by Drainage Tubes After Thoracoscopic Surgery · NA · not yet recruiting
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NCT04336046 — Ultrasound Guided Bilateral Erector Spinae Block as Analgesia for Adolescent Idiopathic Scoliosis Correction · NA · suspended

Other Zagazig University trials

Trials by the same sponsor.

NCT07423676 — Comparison Between Two Drugs in Sedation of Upper GI Endoscopy · not yet recruiting
NCT07418307 — Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block · NA · not yet recruiting
NCT07435025 — Surgery for Obstructed Gastric Carcinoma · NA · active not recruiting
NCT07330375 — Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia · Phase 3 · not yet recruiting
NCT07309731 — Impact OF Cooled Versus Thermal Radiofrequency Denervation In Management Of Chronic Lumber Facet Joint Pain · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05041270 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Zagazig University
Last refreshed: 12 May 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05041270.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing