Last reviewed · How we verify
NCT05041036
Individual Patient Compassionate Use of Nirogacestat
trial testing Nirogacestat (Gamma Secretase Inhibitor) in Desmoid Tumor. Available.
Quick facts
| Lead sponsor | SpringWorks Therapeutics, Inc. |
|---|---|
| Status | AVAILABLE |
| Study type | EXPANDED_ACCESS |
Drugs / interventions tested
- Nirogacestat (Gamma Secretase Inhibitor) — full drug profile →
Conditions studied
- Desmoid Tumor — all drugs for Desmoid Tumor →
- NOTCH Gene Mutation Positive Tumors — all drugs for NOTCH Gene Mutation Positive Tumors →
Sponsor
SpringWorks Therapeutics, Inc. — full company profile →
Who can join
Eligibility, any sex, with Desmoid Tumor or NOTCH Gene Mutation Positive Tumors. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This program is being offered on a patient by patient basis and will require company, Institutional Review Board/Independent Ethics Committee, and applicable competent authority approval.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Modulation of Notch Signaling by Small-Molecular Compounds and Its Potential in Anticancer Studies.
Czerwonka A, Kałafut J, Nees M. · · 2023 · cited 8× · PMID 37760535 · DOI 10.3390/cancers15184563
Verify or expand the search:
- PubMed search for NCT05041036
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Desmoid Tumor
Currently open trials in the same condition.
- NCT07176689 — Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) · Phase 4 · recruiting
- NCT07170644 — A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) · Phase 2 · active not recruiting
- NCT07461246 — Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare) · active not recruiting
- NCT05949099 — Study of Cryoablation and Nirogacestat for Desmoid Tumor · Phase 2 · recruiting
Other SpringWorks Therapeutics, Inc. trials
Trials by the same sponsor.
- NCT07279233 — To Assess the Enzyme Inducing Effects of Carbamazepine on the PK of Mirdametinib in Healthy Participants · Phase 1 · completed
- NCT07259330 — To Determine the Effect of CYP Induction Following Administration of Nirogacestat in Healthy Adult Male Participants · Phase 1 · active not recruiting
- NCT07176689 — Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) · Phase 4 · recruiting
- NCT07171619 — Evaluate the Effects of Famotidine or Rabeprazole on the PK of Nirogacestat · Phase 1 · completed
- NCT07170644 — A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) · Phase 2 · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05041036 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by SpringWorks Therapeutics, Inc.
- Last refreshed: 1 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05041036.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing