NCT05037591 is a EARLY_PHASE1 clinical trial of Sea grapes extract 1.68 g/70kg BW in Obesity, sponsored by State Islamic University of Sunan Kalijaga Yogyakarta.

Who is sponsoring NCT05037591?

NCT05037591 is sponsored by State Islamic University of Sunan Kalijaga Yogyakarta.

What drugs are being tested in NCT05037591?

Interventions in NCT05037591: Sea grapes extract 1.68 g/70kg BW, Placebo.

What condition does NCT05037591 study?

NCT05037591 studies Obesity, Aging, Diabetes.

Is NCT05037591 still recruiting?

NCT05037591 is currently completed. Last updated 16 September 2021.

Last reviewed 2021-09-16 · How we verify

NCT05037591

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Sea Grapes-antioxidants Extract in Obese Men : 4 Weeks Randomized-Double Blind Controlled Trial

Completed EARLY_PHASE1 Last updated 16 September 2021

What this trial tests

EARLY_PHASE1 trial testing Sea grapes extract 1.68 g/70kg BW in Obesity in 70 participants. Completed in 15 September 2021.

Timeline

1 August 2021

Primary endpoint
7 September 2021

15 September 2021

Quick facts

Lead sponsor	State Islamic University of Sunan Kalijaga Yogyakarta
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	70
Start date	1 August 2021
Primary completion	7 September 2021
Estimated completion	15 September 2021
Sites	1 location across Indonesia

Drugs / interventions tested

Sea grapes extract 1.68 g/70kg BW — full drug profile →
Placebo

Conditions studied

Obesity — all drugs for Obesity →
Aging — all drugs for Aging →
Diabetes — all drugs for Diabetes →

Sponsor

State Islamic University of Sunan Kalijaga Yogyakarta

Who can join

Adults 19 to 60, male only, with Obesity or Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Doses of 150 mg/kg BW (30 mg/200g BW) sea grape extract in a previous pre-clinical trial, showed that it could improve blood glucose, total cholesterol and serum PGC-1 levels in rats fed a diet high in fat and cholesterol. In addition, you also have hepatoprotective activity (aka non-toxic) in diabetic mice. Previous research, is an in vivo (Pre-clinical) study that has not represented the benefits or efficacy of sea grape extract on variables tested in humans. Therefore, this clinical trial was conducted to support the effect of sea grape extract-antioxidant on blood glucose, total cholesterol, and PGC-1 levels in obese men for 4 weeks using a Randomized-Double Blind Controlled Trial.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Metabolomic Assay, Computational Screening, and Pharmacological Evaluation of <i>Caulerpa racemosa</i> as an Anti-obesity With Anti-aging by Altering Lipid Profile and Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-α Levels.
Permatasari HK, Nurkolis F, Hardinsyah H, Taslim NA, et al · · 2022 · cited 19× · PMID 35911110 · DOI 10.3389/fnut.2022.939073
Could Natural Products Help in the Control of Obesity? Current Insights and Future Perspectives.
Park J, Nurkolis F, Won H, Yang J, et al · · 2023 · cited 6× · PMID 37764380 · DOI 10.3390/molecules28186604

Verify or expand the search:

Other recruiting trials for Obesity

Currently open trials in the same condition.

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NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
NCT07272837 — Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass · recruiting
NCT07481630 — A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoart · Phase 3 · recruiting
NCT07527195 — Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscl · Phase 1 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05037591 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by State Islamic University of Sunan Kalijaga Yogyakarta
Last refreshed: 16 September 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05037591.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing