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NCT05036148: MHCZECH

Malignant Hyperthermia in Czech Republic: Description of the Biggest Slavonic Group of Patients Investigated for Risk of Malignant Hyperthermia

Completed Last updated 15 April 2022
What this trial tests

trial testing Data analysis in Malignant Hyperthermia in 286 participants. Completed in 31 December 2021.

Timeline
1 September 2021
Primary endpoint
31 December 2021
31 December 2021

Quick facts

Lead sponsorBrno University Hospital
StatusCompleted
Study typeOBSERVATIONAL
Enrollment286
Start date1 September 2021
Primary completion31 December 2021
Estimated completion31 December 2021
Sites1 location across Czechia

Drugs / interventions tested

Conditions studied

Sponsor

Brno University Hospital

Who can join

Adults 1 Month to 99, any sex, with Malignant Hyperthermia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The Academic centre for Malignant Hyperthermia of Masaryk University (ACMHMU) was established in 2021 in Brno, Czech Republic and consists of four academic departments of Medical Faculty of Masaryk University in two tertiary university hospitals, University Hospital Brno and St. Anne Faculty Hospital. These departments collaborated and operated since 2002 and since 2019 is Brno one of the of centre of EMHG (www.emhg.org). Aim of this study was to describe the Czech and Slovak (CZ-SK) cohort of MHS patients, the biggest Slavonic MHS cohort known by now, and to fill the knowledge gap about the Slavonic population in perspective of MH.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Malignant Hyperthermia in Slavonic cohort - clinical and genetic findings beyond standard diagnostics.
    Klincová M, Zídková J, Réblová K, Štěpánková D, et al · · 2026 · PMID 41913278 · DOI 10.1186/s13023-026-04339-w

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