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NCT05027724: TROPIC

Technology Assisted Solutions for the Recognition of Objective Physiological Indicators of Post-Coronavirus-19 Fatigue

Completed Last updated 20 May 2022
What this trial tests

trial in Covid19 in 108 participants. Completed in 5 November 2021.

Timeline
17 May 2021
Primary endpoint
5 November 2021
5 November 2021

Quick facts

Lead sponsorUniversity of Dublin, Trinity College
StatusCompleted
Study typeOBSERVATIONAL
Enrollment108
Start date17 May 2021
Primary completion5 November 2021
Estimated completion5 November 2021
Sites1 location across Ireland

Conditions studied

Sponsor

University of Dublin, Trinity College

Who can join

Adults 18 to 95, any sex, with Covid19 or Post Viral Fatigue. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Preliminary research from our group indicates that up to half of COVID-19 patients are experiencing symptoms consistent with severe fatigue a median of 10 weeks after their initial illness, while almost one third of those previously employed have not returned to work. At present, most clinical and research measurements of fatigue have relied upon self-reported perception of sensations such as exhaustion or weariness. Using such tools, there is an inherent challenge for clinicians in differentiating between patients who are experiencing fatigue at a psychosocial level, versus those who are actively physiologically and neurocognitively deconditioned. The TROPIC study will use our existing clinical expertise and technology assisted solutions to address features of post-COVID-19 fatigue by quantifying physiological signatures of adverse sequelae in adult patients previously diagnosed with COVID-19, who are now COVID-19 negative. Our suite of assessments will encompass four systems; physical deconditioning, orthostatic instability, neurocognitive deficits and respiratory sequelae. This will not only inform accurate objective diagnostics of post-COVID-19 Chronic Fatigue Syndrome, but will also guide clinicians in directing the most appropriate therapeutic interventions with maximum efficacy and specificity, bringing not only patient-related but also health system and economic benefits.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Orthostatic Intolerance in Adults Reporting Long COVID Symptoms Was Not Associated With Postural Orthostatic Tachycardia Syndrome.
    Monaghan A, Jennings G, Xue F, Byrne L, et al · · 2022 · cited 30× · PMID 35309052 · DOI 10.3389/fphys.2022.833650
  2. Predictors of Submaximal Exercise Test Attainment in Adults Reporting Long COVID Symptoms.
    Romero-Ortuno R, Jennings G, Xue F, Duggan E, et al · · 2022 · cited 12× · PMID 35566502 · DOI 10.3390/jcm11092376
  3. Orthostatic intolerance in adults with long COVID was not associated with postural orthostatic tachycardia syndrome
    Monaghan A, Jennings G, Xue F, Byrne L, et al · · 2021 · cited 1× · DOI 10.1101/2021.12.19.21268060
  4. A novel methodology for the synchronous collection and multimodal visualisation of continuous neurocardiovascular and neuromuscular physiological data in adults with long COVID
    Xue F, Monaghan A, Jennings G, Byrne L, et al · · 2021 · DOI 10.1101/2021.12.24.21268370

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Other recruiting trials for Covid19

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05027724.

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