NCT05025189

The Effect of Grape Consumption on Increasing the Good Bacteria in the Human Intestine

Completed NA Last updated 6 May 2023

What this trial tests

NA trial testing Table Grape Powder in Healthy in 20 participants. Completed in 30 July 2021.

Timeline

5 October 2020

Primary endpoint
6 March 2021

30 July 2021

Quick facts

Lead sponsor	University of California, Los Angeles
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	20
Start date	5 October 2020
Primary completion	6 March 2021
Estimated completion	30 July 2021
Sites	1 location across United States

Drugs / interventions tested

• Table Grape Powder
• Beige Diet

Conditions studied

• Healthy — all drugs for Healthy →

Sponsor

University of California, Los Angeles

Who can join

Adults 18 to 55, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This pilot study will assess the ability of daily consumption of one dose (2 servings) of freeze-dried whole table grape powder, made from conventionally grown grapes to alter the composition of the bacteria that live in the intestines in healthy subjects. The grape powder contains 46g of individually quick frozen (IQF) grapes, which is equivalent to 252g fresh fruit. 20 subjects will will consume the beige diet for 4 weeks followed by one dose (two servings) of standardized Freeze-Dried Whole Table Grape Powder (46g) daily for 4 weeks. The primary objective of this pilot study is to determine changes in the gut microbiome. Stool samples will be collected at 4 and 8 weeks for bacterial DNA to determine changes in the bacteria that live in the intestines. You will be asked to avoid foods rich in polyphenols including dark chocolate and cocoa products, dried herbs, berries, coffee, tea, flaxseeds, nuts (chestnut, hazelnut), olive and artichoke for the duration of the study.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Effect of Standardized Grape Powder Consumption on the Gut Microbiome of Healthy Subjects: A Pilot Study.
   Yang J, Kurnia P, Henning SM, Lee R, et al · · 2021 · cited 34× · PMID 34836220 · DOI 10.3390/nu13113965