NCT05021341 (BBD) is a NA clinical trial of Berberine in Glycemia, sponsored by Lindenwood University.

Who is sponsoring NCT05021341?

NCT05021341 is sponsored by Lindenwood University.

What drugs are being tested in NCT05021341?

Interventions in NCT05021341: Berberine, Dihydroberberine 200, Dihydroberberine 100, Placebo.

Is NCT05021341 still recruiting?

NCT05021341 is currently completed. Last updated 25 August 2021.

Last reviewed 2021-08-25 · How we verify

NCT05021341: BBD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Bioavailability of Berberine and Dihydroberberine and Their Impact on Glycemia

Completed NA Last updated 25 August 2021

What this trial tests

NA trial testing Berberine in Glycemia in 5 participants. Completed in 4 November 2020.

Timeline

22 June 2020

Primary endpoint
4 November 2020

4 November 2020

Quick facts

Lead sponsor	Lindenwood University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	other
Enrollment	5
Start date	22 June 2020
Primary completion	4 November 2020
Estimated completion	4 November 2020
Sites	1 location across United States

Drugs / interventions tested

Berberine — full drug profile →
Dihydroberberine 200
Dihydroberberine 100
Placebo

Conditions studied

Glycemia — all drugs for Glycemia →

Sponsor

Lindenwood University

Who can join

Adults 18 to 45, male only, with Glycemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine the bioavailability of berberine and dihydroberberine and their impact on changes in plasma concentrations of glucose and insulin.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Effects of Berberine on Atherosclerosis.
Rui R, Yang H, Liu Y, Zhou Y, et al · · 2021 · cited 36× · PMID 34899318 · DOI 10.3389/fphar.2021.764175
Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial.
Moon JM, Ratliff KM, Hagele AM, Stecker RA, et al · · 2021 · cited 19× · PMID 35010998 · DOI 10.3390/nu14010124

Verify or expand the search:

Other trials of Berberine

Trials testing the same drug.

NCT07420231 — Evaluation of the Synergistic Effect of Combining a Prebiotic and a Postbiotic on Intestinal Discomfort · NA · not yet recruiting
NCT07480018 — Berberine Supplementation, Sprint Interval Training, and Immune Function Study · NA · recruiting
NCT06911983 — Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 Diabete · NA · not yet recruiting
NCT05720299 — A Clinical Study to Evaluate the Effects of Akkermansia Muciniphila and Berberine on Prediabetes Among Obese Subjects. · NA · completed
NCT06514274 — Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Era · Phase 4 · completed

Other recruiting trials for Glycemia

Currently open trials in the same condition.

NCT06951386 — The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabol · NA · recruiting

Other Lindenwood University trials

Trials by the same sponsor.

NCT07387991 — Evaluating the Ability of a Multi-Strain Postbiotic to Impact Inflammation, Immune Components, Gastrointestinal Symptoms · NA · not yet recruiting
NCT07388264 — Impact of Weizmannia (Bacillus) Coagulans JBI-YZ6.3 on Gut Health and Fecal Microbiome Changes · NA · recruiting
NCT07310108 — Evaluation of Cordyceps Militaris M2-116-04 for Its Potential Sport and Exercise Nutrition Applications in Healthy Activ · NA · completed
NCT06672952 — Dose-Response Impact of Glucosyl-Hesperidin (CitraPeak) on Exercise Performance, Blood Flow, Stress, Cognition, and Othe · NA · recruiting
NCT07502924 — Dose-Response Impact of Geranylgeraniol (GG) Supplementation on Muscle Health · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05021341 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Lindenwood University
Last refreshed: 25 August 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05021341.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing