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NCT05019313
Diaphragm Ultrasound Evaluation During Weaning From Mechanical Ventilation in the Positive COVID-19 Patient
trial testing Evaluation of diaphragmatic contractility by ultrasound in COVID-19 Pneumonia in 38 participants. Status unknown.
30 June 2021
Quick facts
| Lead sponsor | Azienda Sanitaria-Universitaria Integrata di Udine |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 38 |
| Start date | 1 April 2020 |
| Primary completion | 30 June 2021 |
| Estimated completion | 31 March 2022 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Evaluation of diaphragmatic contractility by ultrasound
Conditions studied
- COVID-19 Pneumonia — all drugs for COVID-19 Pneumonia →
- Diaphragm Disease — all drugs for Diaphragm Disease →
Sponsor
Azienda Sanitaria-Universitaria Integrata di Udine — full company profile →
Who can join
Adults 18 to 99, any sex, with COVID-19 Pneumonia or Diaphragm Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Hypoxemic acute respiratory failure is one of the main COVID-19 patients complication that lead to in intensive care hospitalization. This complication determines a variable mortality from 25 to 30%. To correct hypoxemia (often severe) is often needed non-invasive or invasive mechanical ventilation. Mechanical ventilation is not a therapeutic strategy, but it allows to extend the time-to-recovery necessary to solve COVID-19 respiratory failure cause. Calibration of ventilatory support is essential to ensure adequate time-to-recovery without contributing to onset lung and / or diaphragmatic damage. Basal diaphragmatic activity assessment, device for administering the oxygenation support choice and setting ventilatory support parameters are decisive. Ultrasound is the best method for measuring diaphragmatic work. The aim of this study is to evaluate the diaphragmatic thickening fraction in COVID-19 patients admitted to Intensive Care Unit (ICU) for acute respiratory failure and to record its function on weaning.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Diaphragm ultrasound evaluation during weaning from mechanical ventilation in COVID-19 patients: a pragmatic, cross-section, multicenter study.
Vetrugno L, Orso D, Corradi F, Zani G, et al · · 2022 · cited 30× · PMID 35989352 · DOI 10.1186/s12931-022-02138-y
Verify or expand the search:
- PubMed search for NCT05019313
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05019313 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Azienda Sanitaria-Universitaria Integrata di Udine
- Last refreshed: 24 August 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05019313.
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