NCT05015543: MMH

Physical Training in Glioblastoma Patients During Cytotoxic Therapy

Completed NA Last updated 12 December 2024

What this trial tests

NA trial testing Personal Training Program in Glioblastoma in 54 participants. Completed in 1 December 2024.

Timeline

23 July 2020

Primary endpoint
17 October 2024

1 December 2024

Quick facts

Lead sponsor	University Hospital Muenster
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	supportive care
Enrollment	54
Start date	23 July 2020
Primary completion	17 October 2024
Estimated completion	1 December 2024
Sites	1 location across Germany

Drugs / interventions tested

• Personal Training Program

Conditions studied

• Glioblastoma — all drugs for Glioblastoma →

Sponsor

University Hospital Muenster

Who can join

18 and older, any sex, with Glioblastoma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the present study is the prospective controlled use of physical activity in a collective of patients with glioblastoma after surgery and concomitant radiation/chemotherapy and during adjuvant cytotoxic therapy. The research question is whether physical exercise is feasible and whether patients benefit physically and mentally from the activities performed. For this purpose, specific training units under the supervision of a certified trainer and sports scientist as well as standardized sports medical test procedures are implemented. Beyond the instructed training, general physical activity phases are recorded electronically using a pedometer/activity tracker, which is worn at all times.

It will be examined whether the individual training program

1. improves physical fitness
2. increases quality of life/life satisfaction throughout the intervention
3. can be detected in blood due to increased concentrations of brain-derived neurotrophic factor 1 (BDNF-1) (voluntary)

The measurements should be taken before and 8, 16 and 24 weeks after the start of training.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Conceptual development of an intensive exercise program for glioma patients (ActiNO): summary of clinical experience.
   Jost J, Müther M, Brandt R, Altuner U, et al · · 2023 · cited 7× · PMID 37306887 · DOI 10.1007/s11060-023-04354-y
2. A Holistic Approach to Hard-to-Treat Cancers: The Future of Immunotherapy for Glioblastoma, Triple Negative Breast Cancer, and Advanced Prostate Cancer.
   Puig-Saenz C, Pearson JRD, Thomas JE, McArdle SEB. · · 2023 · cited 4× · PMID 37626597 · DOI 10.3390/biomedicines11082100
3. Maximal cardiopulmonary exercise testing in glioblastoma patients undergoing chemotherapy: assessment of feasibility, safety, and physical fitness status.
   Jost J, Völker K, Brandt R, Stummer W, et al · · 2024 · cited 3× · PMID 38561565 · DOI 10.1007/s11060-024-04629-y
4. Physical activity and glioblastoma: a paradigm shift in neuro-oncology therapy.
   Xie L, Wang F. · · 2025 · cited 1× · PMID 40809025 · DOI 10.3389/fonc.2025.1638060
5. Enhancing cardiorespiratory fitness and quality of life in high-grade glioma through an intensive exercise intervention during chemotherapy: Proof of concept.
   Jost-Engl J, Ketter R, Brandt R, Völker K, et al · · 2025 · PMID 40726159 · DOI 10.1093/neuonc/noaf176
6. P08.11.A A subgroup analysis of utilities from European patients using tumor treating fields for glioblastoma
   · 2022
7. P08.10.B Family-centred care in neuro-oncology: a longitudinal mixed-methods feasibility study
   · 2022
8. P08.09.A Improving support for family carers: Creating a cross-sector collaborative working group
   · 2022