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NCT05015049

Hypertensive Disorders of Pregnancy - the Neonatal Burden of Disease

Active, enrolled Last updated 15 October 2024
What this trial tests

trial in Hypertension in Pregnancy in 823,957 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline
1 July 2021
Primary endpoint
30 September 2025
30 September 2025

Quick facts

Lead sponsorImperial College London
StatusActive, enrolled
Study typeOBSERVATIONAL
Enrollment823,957
Start date1 July 2021
Primary completion30 September 2025
Estimated completion30 September 2025
Sites1 location across United Kingdom

Conditions studied

Sponsor

Imperial College London

Who can join

Eligibility, any sex, with Hypertension in Pregnancy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Around one in ten women have high blood pressure in pregnancy. This is potentially serious, with risks to the woman and her baby. Whilst maternal deaths from high blood pressure in pregnancy are now rare in the UK, blood pressure problems in pregnancy still cause many stillbirths and early births. Studies have shown that women of Black and Asian backgrounds are more likely to have worse pregnancy outcomes when blood pressure problems in pregnancy develop. This study aims to: i) describe the burden of disease of high blood pressure in pregnancy amongst babies admitted to neonatal units on a national scale. ii) investigate outcomes for babies born to women with high blood pressure in pregnancy admitted to UK neonatal units across maternal ethnic groups. To complete this study, we will use the National Neonatal Research Database, which holds population-level data for all babies admitted to neonatal units (where unwell babies receive care) in the UK. We will look at records of babies admitted to neonatal units in England and Wales between 2012 and 2020. The records will include information on over half a million babies and their mothers. We will assess how many babies admitted to neonatal units were born to women who had high blood pressure in pregnancy. We will report the outcomes of these babies, and how they compare to babies born to women without high blood pressure in pregnancy. We will analyse whether outcomes for babies born to women with high blood pressure in pregnancy varies according to maternal ethnicity, and investigate what may be driving differences we find.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. The contribution of hypertensive disorders of pregnancy to late preterm and term admissions to neonatal units in the UK 2012-2020 and opportunities to avoid admission: A population-based study using the National Neonatal Research Database.
    Conti-Ramsden F, Fleminger J, Lanoue J, Chappell LC, et al · · 2024 · cited 14× · PMID 37337344 · DOI 10.1111/1471-0528.17574
  2. The Contribution of Hypertensive Disorders of Pregnancy to Neonatal Unit Admissions and Iatrogenic Preterm Delivery at < 34<sup>+0</sup> Weeks' Gestation in the UK: A Population-Based Study Using the National Neonatal Research Database.
    Conti-Ramsden F, Fleminger J, Lanoue J, Chappell LC, et al · · 2025 · cited 4× · PMID 39370603 · DOI 10.1111/1471-0528.17976

Verify or expand the search:

Other recruiting trials for Hypertension in Pregnancy

Currently open trials in the same condition.

Other Imperial College London trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

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