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NCT05012722: ASHFCKD
Arterial Stiffness in Heart Failure and Chronic Kidney Disease
trial testing Sphygmocor CVMS (Atocr Medical, Sydney Australia) PWV measurement in Arterial Stiffness in 119 participants. Completed in 13 December 2023.
13 December 2023
Quick facts
| Lead sponsor | University Hospitals Coventry and Warwickshire NHS Trust |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 119 |
| Start date | 30 January 2022 |
| Primary completion | 13 December 2023 |
| Estimated completion | 13 December 2023 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Sphygmocor CVMS (Atocr Medical, Sydney Australia) PWV measurement
Conditions studied
- Arterial Stiffness — all drugs for Arterial Stiffness →
Sponsor
University Hospitals Coventry and Warwickshire NHS Trust
Who can join
Adults 60 to 100, any sex, with Arterial Stiffness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This observational study is assessing the effects that arterial stiffness may have on patients with heart failure (HF) and chronic kidney disease (CKD). Arterial stiffness will be measured by assessing pulse wave velocity (PWV). Carotid- Femoral PWV is the gold standard in measuring arterial stiffness non- invasively. Many studies have shown increasing PWV is a predictor of cardiovascular events, but the significance of increasing PWV as a surrogate marker for the potential worsening (decompensation) of HF or CKD has not been explored. This study aims to investigate patients with HF and CKD by assessing PWV while in a decompensated state and again when in a stable condition after 4 weeks of discharge to investigate a link between decompensation and rise of arterial stiffness. The research team aim to recruit 120 patients in this study with 40 patients in each of the 3 groups- heart failure with reduced ejection fraction (HFrEF), heart failure with preserved ejection fraction (HFpEF) and acute kidney injury (AKI). All AKI patients would have had known CKD (stages 3a, 3b or 4). The study participants will be initially recruited in hospital while admitted in an acute state and tests including bloods, ECG, echocardiography and PWV will be performed. The tests (excluding echocardiography) will be repeated 4 weeks after discharge. There is no intervention in this study. The study seeks to improve the understanding of the role of the vasculature in the development of acute HF in the two common types- HFrEF and HFpEF. As CKD is a common comorbidity in heart failure patients we felt that a study of the behaviour of arterial stiffness in this cohort will add to this understanding. If arterial stiffness is found to be an important component of the HF syndrome therapeutic interest could be focused at managing arterial stiffness with novel therapy.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Arterial stiffness in acute decompensated heart failure and acute kidney injury: a prospective observational cohort study protocol in a tertiary hospital setting.
Joshi M, Tran P, Barber TM, Khweir L, et al · · 2025 · cited 1× · PMID 40550719 · DOI 10.1136/bmjopen-2024-097718
Verify or expand the search:
- PubMed search for NCT05012722
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05012722 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospitals Coventry and Warwickshire NHS Trust
- Last refreshed: 18 June 2024
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