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NCT05007535: SPECTRUM

Tissue Characterization and Primary Percutaneous Coronary Intervention Guidance Using Intravascular Ultrasound

Status unknown Last updated 18 January 2023
What this trial tests

trial in ST Elevation Myocardial Infarction in 200 participants. Status unknown.

Timeline
10 November 2020
Primary endpoint
2 February 2023
2 February 2023

Quick facts

Lead sponsorErasmus Medical Center
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment200
Start date10 November 2020
Primary completion2 February 2023
Estimated completion2 February 2023
Sites1 location across Netherlands

Conditions studied

Sponsor

Erasmus Medical Center

Who can join

18 and older, any sex, with ST Elevation Myocardial Infarction or Acute Myocardial Infarction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This prospective, single arm, observational cohort study is designed to assess the safety and efficacy of (high-definition) intravascular ultrasound (HD-IVUS) as guidance for primary percutaneous coronary intervention (PCI) and to assess culprit lesion plaque characteristics and thrombus morphology in patients with ST-elevation myocardial infarction (STEMI). Objectives: * To assess clinical outcomes after IVUS-guided primary PCI in STEMI patients. * To assess IVUS-guided optimization in STEMI patients. * To assess culprit lesion plaque characteristics in STEMI patients with HD-IVUS. * To assess and quantify thrombus in STEMI patients with HD-IVUS. * To explore HD-IVUS derived predictors for clinically relevant aspiration thrombectomy.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

  1. The Usefulness of Intracoronary Imaging in Patients with ST-Segment Elevation Myocardial Infarction.
    Karamasis GV, Varlamos C, Benetou DR, Kalogeropoulos AS, et al · · 2023 · cited 7× · PMID 37762832 · DOI 10.3390/jcm12185892
  2. Unlocking the Secrets of Acute Coronary Syndromes Using Intravascular Imaging: From Pathophysiology to Improving Outcomes.
    Apostolos A, Karanasos A, Ktenopoulos N, Tsalamandris S, et al · · 2024 · cited 6× · PMID 39685545 · DOI 10.3390/jcm13237087
  3. Culprit lesion plaque characterization and thrombus grading by high-definition intravascular ultrasound in patients with ST-segment elevation myocardial infarction.
    Groenland FTW, Ziedses des Plantes AC, Neleman T, Scoccia A, et al · · 2023 · cited 6× · PMID 37232425 · DOI 10.1002/ccd.30699
  4. Tissue characterisation and primary percutaneous coronary intervention guidance using intravascular ultrasound: rationale and design of the SPECTRUM study.
    Groenland FTW, Mahmoud KD, Neleman T, Ziedses des Plantes AC, et al · · 2022 · cited 5× · PMID 35437257 · DOI 10.1136/openhrt-2021-001955
  5. Patterns of intracoronary thrombus by high-definition intravascular ultrasound.
    Groenland FTW, Ligthart JMR, Witberg KT, Daemen J. · · 2022 · cited 5× · PMID 34984982 · DOI 10.4244/eij-d-21-00796

Verify or expand the search:

Other recruiting trials for ST Elevation Myocardial Infarction

Currently open trials in the same condition.

Other Erasmus Medical Center trials

Trials by the same sponsor.

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05007535.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing