Assessing The Role Of Intravenous Lipid Emulsion As A Life Saving Therapy In Pesticides Toxicity: A Randomized Controlled Trial In Poison Control Center Of Ain Shams University Hospitals

NCT05006638 Phase 4 UNKNOWN

Intravenous lipid emulsion is an established, effective treatment for local anesthetic systemic toxicity. It is also efficacious in animal models of severe cardiotoxicity caused by a number of other medications. Recent case reports of successful resuscitation suggest the efficacy of lipid emulsion infusion for treating non-local anesthetic overdoses across a wide spectrum of drugs. The present study will focus on the potential role of intravenous lipid emulsion as an adjuvant therapy in pesticides toxicity.

Details

Lead sponsor	Aya Sabry Mohamed Mohamed
Phase	Phase 4
Status	UNKNOWN
Enrolment	62
Start date	2022-12
Completion	2023-12

Conditions

• Pesticide Poisoning

Interventions

• Lipid Emulsion, Intravenous
• Atropine
• Toxogonin
• Sodium Bicarbonate Powder and ondansetron

Primary outcomes

• mortality rate reduction — 1 year
  the primary end point is to lower the mortality rate for patients poisoned with pesticides
• organ damage reduction — 1 year
  another primary end point is to reduce organ damage and injury for survivors

Countries

Egypt