Who is sponsoring NCT05005377?

NCT05005377 is sponsored by Tehran University of Medical Sciences.

What drugs are being tested in NCT05005377?

Interventions in NCT05005377: Socket Preservation with Platelet-Rich Fibrin, Socket Preservation with Freeze-Dried Bone Allograft.

What condition does NCT05005377 study?

NCT05005377 studies Alveolar Ridge Augmentation, Bone Transplantation.

Is NCT05005377 still recruiting?

NCT05005377 is currently completed. Last updated 13 August 2021.

Last reviewed 2021-08-13 · How we verify

NCT05005377

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Peri-Implant Soft and Hard Tissue Stability Following Socket Preservation

Completed NA Last updated 13 August 2021

What this trial tests

NA trial testing Socket Preservation with Platelet-Rich Fibrin in Alveolar Ridge Augmentation in 48 participants. Completed in 1 March 2020.

Timeline

1 December 2016

Primary endpoint
1 December 2018

1 March 2020

Quick facts

Lead sponsor	Tehran University of Medical Sciences
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	48
Start date	1 December 2016
Primary completion	1 December 2018
Estimated completion	1 March 2020

Drugs / interventions tested

Socket Preservation with Platelet-Rich Fibrin
Socket Preservation with Freeze-Dried Bone Allograft

Conditions studied

Alveolar Ridge Augmentation — all drugs for Alveolar Ridge Augmentation →
Bone Transplantation — all drugs for Bone Transplantation →

Sponsor

Tehran University of Medical Sciences

Who can join

18 and older, any sex, with Alveolar Ridge Augmentation or Bone Transplantation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The viability of Platelet Rich Fibrin (PRF) on enhancement of osseous and associated tissue healing has been substantiated well in literature. This study aimed to assess peri-implant soft and hard tissue changes after prosthetic loading of implants following socket preservation with platelet-rich fibrin (PRF) and freeze-dried bone allograft (FDBA) in a 12-month period. This Study evaluated 48 patients who were randomly divided into two groups for anterior ridge preservation with PRF and FDBA. At 12 months after implant placement and prosthetic delivery, bone loss was evaluated radiographically while soft tissue changes were evaluated by measuring gingival recession, papilla index, and bleeding on probing (BOP). The differences between the PRF and FDBA groups were analyzed using Fisher's exact test and student's t-test (P\<0.05).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The effect of platelet-rich fibrin (PRF) versus freeze-dried bone allograft (FDBA) used in alveolar ridge preservation on the peri-implant soft and hard tissues: a randomized clinical trial.
Azangookhiavi H, Habibzadeh S, Zahmatkesh H, Mellati E, et al · · 2024 · cited 6× · PMID 38877446 · DOI 10.1186/s12903-024-04478-1

Verify or expand the search:

Other recruiting trials for Alveolar Ridge Augmentation

Currently open trials in the same condition.

NCT06783660 — PeptiCol EZgraft in the Extraction Socket Preservation Process After Tooth Extraction · NA · recruiting

Other Tehran University of Medical Sciences trials

Trials by the same sponsor.

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NCT06876194 — The Effect of Music on the Sedation Quality Among Children in the Emergency Department. · Phase 3 · completed
NCT06721273 — Iodine Supplementation and Fertility Parameters · NA · not yet recruiting
NCT07014397 — Effect of Valaciclovir on Inter-Appointment Pain in Endodontic Treatment of Necrotic Teeth · NA · completed
NCT06615934 — Effects of Aerobic and Resistance Exercises on Inpatients Liver Transplantation Recipients · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05005377 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Tehran University of Medical Sciences
Last refreshed: 13 August 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05005377.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing