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NCT05003765
Are Superficial Parasternal Intercostal Plane (SPIP) Blocks With Bupivacaine and With or Without Adjuvants Helpful for Post-operative Pain After Coronary Artery Bypass Grafting?
NA trial testing Bupivacaine 0.25% Injectable Solution in Post-operative Pain Management in 200 participants. Status unknown.
1 May 2022
Quick facts
| Lead sponsor | Wayne State University |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | supportive care |
| Enrollment | 200 |
| Start date | 6 August 2020 |
| Primary completion | 1 May 2022 |
| Estimated completion | 1 May 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Bupivacaine 0.25% Injectable Solution — full drug profile →
- Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 200 mg — full drug profile →
- Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 200 mg, Buprenorphine 300 mcg — full drug profile →
Conditions studied
- Post-operative Pain Management — all drugs for Post-operative Pain Management →
Sponsor
Wayne State University
Who can join
Adults 18 to 100, any sex, with Post-operative Pain Management. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to determine whether the addition of the superficial parasternal intercostal plane (SPIP) block alone (30cc of 0.25% bupivacaine) or plus Magnesium (200mg of magnesium sulfate) or plus Magnesium + Buprenorphine (300mcg) as adjuvants can improve post-operative pain in patients undergoing cardiothoracic surgery, specifically, coronary artery bypass grafting (CABG)
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Superficial Parasternal Intercostal Plane Blocks (SPIB) With Buprenorphine, Magnesium, and Bupivacaine for Management of Pain in Coronary Artery Bypass Grafting.
Krishnan S, Desai R, Paik P, Cassella A, et al · · 2022 · cited 4× · PMID 36475128 · DOI 10.7759/cureus.30964
Verify or expand the search:
- PubMed search for NCT05003765
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT05590234 — Dexmedetomidine Combined With Bupivacaine for Erector Spinae Plane Block · Phase 1, PHASE2 · completed
Other recruiting trials for Post-operative Pain Management
Currently open trials in the same condition.
- NCT07281118 — Intercostal Cryoanalgesia in Double Lung Transplant Recipients · NA · recruiting
- NCT07250373 — Serratus Posterior Superior Intercostal Plane (SPSIP) Block Versus Intercostal Nerve (ICN) Block in Patients Undergoing · NA · active not recruiting
Other Wayne State University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05003765 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Wayne State University
- Last refreshed: 12 August 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05003765.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing