Last reviewed · How we verify
NCT05003349
Pain Neuroscience Education, Motor Imagery and Action Observation in Patients With Chronic Temporomandibular Disorders.
NA trial testing Occlusal Splint (OS). in TMD in 50 participants. Completed in 12 January 2026.
30 November 2025
Quick facts
| Lead sponsor | University of Gran Rosario |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 31 August 2021 |
| Primary completion | 30 November 2025 |
| Estimated completion | 12 January 2026 |
| Sites | 1 location across Argentina |
Drugs / interventions tested
- Occlusal Splint (OS).
- Pain Neuroscience Education (PNE).
- Motor Imagery (MI).
- Action Observation (AO).
- Jaw and Neck Exercises (JNE)
- Counselling.
Conditions studied
- TMD — all drugs for TMD →
Sponsor
University of Gran Rosario
Who can join
Adults 18 to 65, any sex, with TMD. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of this study will be to verify the additional effect of Pain Neuroscience Education, Motor Imagery and Action Observation on primary outcomes pain intensity and craniofacial pain and disability in patients with chronic temporomandibular disorders (TMD). The secondary outcomes will be pressure pain threshold, temporal summation, conditioned pain modulation, central sensibilization, pain catastrophizing, kinesiophobia. This study will be a doble-blinded randomized clinical trial comprising a sample of 50 participants with orofacial pain of both genders and aged between 18 and 60 years. Subjects will undergo a screening process to identify those presenting a diagnosis of painful TMD confirmed by the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), and then they will be randomized into two groups (G1: Occlusal Splint, Counselling and Jaw and Neck Exercises vs. (G2: Occlusal Splint, Jaw and Neck Exercises plus Pain Neuroscience Education, Motor Imagery and Action Observation). These volunteers will be recruited from the Alisos Group Dentistry Clinic and University of Gran Rosario, (Rosario, Argentina). All patients will wear an occlusal splint designed by dentists. The interventions will be administered twice a week for 5 weeks by a single therapist. Subsequently, patients will be given instructions to perform the exercises at home for 5 weeks. Primary and secondary outcomes will be measured at baseline, 6 weeks and 12 weeks, and at 3 months after the end of treatment (follow-up). All the evaluations will be performed by a blinded physiotherapist.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05003349
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for TMD
Currently open trials in the same condition.
- NCT07304557 — Effects Exercises in Temporomandibular Joint Disorders on Pain, Joint and Tongue Functions · NA · recruiting
- NCT06948162 — Exploration of the Utility of Dental-dedicated MRI for Dentistry · recruiting
- NCT07351812 — Two Treatment Modalities for Myogenous Temporomandibular Disorders · NA · recruiting
Other University of Gran Rosario trials
Trials by the same sponsor.
- NCT07184190 — Effects of Trancutaneous Auriculotemporal Nerve Stimulation · NA · completed
- NCT06046885 — Electrical Stimulation in Older Adults · NA · unknown
- NCT05535088 — Older Adults Virtual Reality · NA · completed
- NCT05433610 — Non-invasive Ventilation in Patients With Cardiac Heart Failure · NA · completed
- NCT05292599 — Effect of a Home-based Versus Supervised Exercise Program in Patients With Migraine · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05003349 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Gran Rosario
- Last refreshed: 15 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05003349.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing