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NCT05003063
Effects of Acetylcholine and Attention on Visual Spatial Representations in the Brain
EARLY_PHASE1 trial testing Donepzil in Visual Perception in 12 participants. Completed in 2 August 2021.
2 August 2021
Quick facts
| Lead sponsor | University of California, Berkeley |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 12 |
| Start date | 4 February 2021 |
| Primary completion | 2 August 2021 |
| Estimated completion | 2 August 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Donepzil — full drug profile →
- Placebo oral tablet — full drug profile →
Conditions studied
- Visual Perception — all drugs for Visual Perception →
- Attention — all drugs for Attention →
- Information Processing — all drugs for Information Processing →
- Cholinergic System — all drugs for Cholinergic System →
Sponsor
University of California, Berkeley
Who can join
Adults 18 to 80, any sex, with Visual Perception or Attention. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study in, healthy human subjects using fMRI and MRS (magnetic resonance spectroscopy) characterizes, how attention and acetylcholine affect visual perception and the brain's representation of the visual environment. Levels of acetylcholine in the cerebral cortex will be enhanced by administration of donepezil, an inhibitor of acetylcholinesterase. Half the subjects will receive donepezil and other half will receive placebo.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05003063
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05003063 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of California, Berkeley
- Last refreshed: 12 August 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05003063.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing