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Dutch National Randomized Study: PSMA-PET/CT As a Triage Tool for Pelvic Lymph Node Dissection in Prostatectomy Patients (PSMA-SELECT)
To determine if the use of Prostate-Specific Membrane Antigen Positron Emission Computer Tomography (PSMA PET/CT) as a selection tool for performing extended lymph node dissection (ePLND) for prostate cancer (PCa) in the primary staging setting results in fewer ePLND procedures and therefore lower overall healthcare costs, lower patient burden in terms of intervention-related complications and morbidity, with comparable disease prognosis, compared to the current European Guideline-recommended standard practice which includes performing ePLND in PCa patients who are candidates for active treatment with a nomogram-calculated lymph node involvement (LNI) risk \>5%.
Details
| Lead sponsor | Canisius-Wilhelmina Hospital |
|---|---|
| Phase | NA |
| Status | RECRUITING |
| Enrolment | 706 |
| Start date | Wed Jul 28 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Prostate Cancer Metastatic
- Prostate Cancer
- Lymph Node Metastases
Interventions
- PSMA-PET/CT
- Nomogram
Countries
Netherlands