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NCT04997980: MOSAIC
AMSA and Amiodarone Study in Cardiac Arrest
trial testing Amiodarone Injection in Out-Of-Hospital Cardiac Arrest in 629 participants. Completed in 31 December 2023.
31 December 2023
Quick facts
| Lead sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 629 |
| Start date | 1 January 2015 |
| Primary completion | 31 December 2023 |
| Estimated completion | 31 December 2023 |
| Sites | 4 locations across Italy, Spain, Norway |
Drugs / interventions tested
- Amiodarone Injection
Conditions studied
- Out-Of-Hospital Cardiac Arrest — all drugs for Out-Of-Hospital Cardiac Arrest →
Sponsor
Fondazione IRCCS Policlinico San Matteo di Pavia
Who can join
Adults 1 to 100, any sex, with Out-Of-Hospital Cardiac Arrest. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Investigators' aim is to assess whether the administration of amiodarone during resuscitation could cause a reduction of the values of the amplitude spectral area (AMSA). Amiodarone is recommended for the treatment of cardiac arrest due to ventricular tachycardia/ventricular fibrillation (VT/VF) ( with a low level of recommendation cause of conflicting results. AMSA is a parameter expressing the amplitude of VF and it has been shown to predict defibrillation success and the return of spontaneous circulation (ROSC). No data are available so far about the impact of amiodarone administration on AMSA values.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
aMplitude spectral area of ventricular fibrillation and amiOdarone Study in patients with out-of-hospital cArdIaC arrest. The MOSAIC study.
Gentile FR, Wik L, Aramendi E, Baldi E, et al · · 2023 · cited 5× · PMID 37255711 · DOI 10.3389/fcvm.2023.1179815
Verify or expand the search:
- PubMed search for NCT04997980
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Amiodarone Injection
Trials testing the same drug.
- NCT06742866 — Efficacy and Safety of Intravenous + Oral Vs. Oral Amiodarone in Preventing Recurrence After Catheter Ablation in Patien · NA · not yet recruiting
- NCT04845607 — Prophylactic Amiodarone for Shockable Cardiac Arrest · Phase 3 · unknown
- NCT03868150 — Prevention of Postop Atrial Fibrillation Through Intraoperative Inducibility of Atrial Fibrillation and Amiodarone Treat · Phase 4 · recruiting
Other recruiting trials for Out-Of-Hospital Cardiac Arrest
Currently open trials in the same condition.
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- NCT06530433 — Enhanced Community First Responder System Evaluation in Singapore · NA · recruiting
- NCT06203847 — The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA · NA · recruiting
- NCT06306625 — REmote COnditioning in Out-of-Hospital Cardiac Arrest · NA · recruiting
- NCT06071910 — Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest · NA · recruiting
Other Fondazione IRCCS Policlinico San Matteo di Pavia trials
Trials by the same sponsor.
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- NCT07356583 — Neonatal Enterovirus Infections in Italy: Virological Characterization, Genomic and Clinical-epidemiological Insights on · recruiting
- NCT07435207 — Thrombotic RIsk FActors in AL-goneurodystrophy · enrolling by invitation
- NCT07263802 — Effect of a Food Supplement on Glycemic Parameters in Patients With Impaired Glucose Metabolism · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04997980 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fondazione IRCCS Policlinico San Matteo di Pavia
- Last refreshed: 8 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04997980.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing