NCT04996979: PENGBlock

Patients With Acute Hip Fractures Will Receive Either the PENG Block or no Block Respectively.

Status unknown NA Last updated 9 August 2021

What this trial tests

NA trial testing Ropivacaine 0.5% Injectable Solution in Hip Fractures in 60 participants. Status unknown.

Timeline

24 May 2021

Primary endpoint
31 May 2022

31 December 2022

Quick facts

Lead sponsor	Singapore General Hospital
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	24 May 2021
Primary completion	31 May 2022
Estimated completion	31 December 2022
Sites	1 location across Singapore

Drugs / interventions tested

• Ropivacaine 0.5% Injectable Solution — full drug profile →
• Placebo

Conditions studied

• Hip Fractures — all drugs for Hip Fractures →

Sponsor

Singapore General Hospital

Who can join

Adults 60 to 100, any sex, with Hip Fractures. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Hip fracture pain is often severe and traditionally managed by systemic opioids which have increased risk of side effects in frail elderly patients. Inadequately controlled pain may lead to delirium which increases mortality and morbidity. The overall aim of this RCT is to investigate the potential for improved pain relief accomplished by the addition of the PENG block to current standard practice of pre-operative analgesia (systemic morphine), compared to the control group, which involves no block (operator will still go through the motion as if performing a block) plus standard pre-operative analgesia.

The investigator hypothesize that the addition of a single shot PENG block at the side of hip fracture in addition to traditional systemic morphine provides good preoperative pain relief on movement and reduces the need for breakthrough opioid requirements. The investigator hypothesize that the interventional group dynamic pain score assessed at 30 minutes after the block compared to control group dynamic pain score at 30 minutes after the "block" will be at least a 3 point difference between the 2 groups .

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Pericapsular nerve group (PENG) block for early pain management of elderly patients with hip fracture: a single-center double-blind randomized controlled trial.
   Lin X, Liu CW, Goh QY, Sim EY, et al · · 2023 · cited 27× · PMID 37055189 · DOI 10.1136/rapm-2022-104117