Who is sponsoring NCT04995926?

NCT04995926 is sponsored by The S.N. Fyodorov Eye Microsurgery State Institution.

What condition does NCT04995926 study?

NCT04995926 studies Limbal Stem-cell Deficiency.

Is NCT04995926 still recruiting?

NCT04995926 is currently recruiting now. Last updated 23 April 2024.

Last reviewed 2024-04-23 · How we verify

NCT04995926

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Labial Mucosal Epithelium Grafting for Corneal Limbus Substitution

Recruiting now NA Last updated 23 April 2024

What this trial tests

NA trial testing Labial mucosal epithelium grafting for corneal limbus substitution in Limbal Stem-cell Deficiency in 20 participants. Currently enrolling.

Timeline

1 July 2021

Primary endpoint
30 May 2024

31 December 2025

Quick facts

Lead sponsor	The S.N. Fyodorov Eye Microsurgery State Institution
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	20
Start date	1 July 2021
Primary completion	30 May 2024
Estimated completion	31 December 2025
Sites	1 location across Russia

Drugs / interventions tested

Labial mucosal epithelium grafting for corneal limbus substitution

Conditions studied

Limbal Stem-cell Deficiency — all drugs for Limbal Stem-cell Deficiency →

Sponsor

The S.N. Fyodorov Eye Microsurgery State Institution

Who can join

Adults 18 to 70, any sex, with Limbal Stem-cell Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Earlier approaches for cornea reepithelization in patients with bilateral LSCD included allogeneic corneal limbus grafting from postmortem donor or livingrelated relatives with concomitant systemic immunosuppression (Cheung and Holland, 2017) and cultivated oral mucosal epithelial transplantation (COMET) (Nishida et al., 2004). The novel surgical technique for corneal re-epithelization were described by Liu et al. (2011) and Choe et al. (2019). In both clinical studies, the autologous labial mucosal epithelium graft was transplanted as a surrogate corneal limbus for purpose of treatment the LSCD. Authors reported positive outcomes in terms of anatomical success and corneal status improvement. The purpose of the study is to evaluate the feasibility of the novel surgical intervention in clinical use.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

Therapeutic Strategies for Restoring Perturbed Corneal Epithelial Homeostasis in Limbal Stem Cell Deficiency: Current Trends and Future Directions.
Masood F, Chang JH, Akbar A, Song A, et al · · 2022 · cited 26× · PMID 36291115 · DOI 10.3390/cells11203247
Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges.
Niu Y, Ji J, Yao K, Fu Q. · · 2024 · cited 25× · PMID 38586868 · DOI 10.1016/j.aopr.2024.02.001
Targeting limbal epithelial stem cells: master conductors of corneal epithelial regeneration from the bench to multilevel theranostics.
Li S, Sun H, Chen L, Fu Y. · · 2024 · cited 16× · PMID 39198892 · DOI 10.1186/s12967-024-05603-y
Understanding the cellular dynamics, engineering perspectives and translation prospects in bioprinting epithelial tissues.
Derman ID, Moses JC, Rivera T, Ozbolat IT. · · 2025 · cited 7× · PMID 39386221 · DOI 10.1016/j.bioactmat.2024.09.025
Tackling visual impairment: emerging avenues in ophthalmology.
Lin F, Su Y, Zhao C, Akter F, et al · · 2025 · cited 4× · PMID 40357281 · DOI 10.3389/fmed.2025.1567159
Diagnostic Algorithm for Surgical Management of Limbal Stem Cell Deficiency.
Malyugin B, Kalinnikova S, Isabekov R, Ostrovskiy D, et al · · 2023 · cited 2× · PMID 36673009 · DOI 10.3390/diagnostics13020199

Verify or expand the search:

Other recruiting trials for Limbal Stem-cell Deficiency

Currently open trials in the same condition.

NCT03957954 — Stem Cell Therapy for Limbal Stem Cell Deficiency · Phase 1 · active not recruiting

Other The S.N. Fyodorov Eye Microsurgery State Institution trials

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04995926 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The S.N. Fyodorov Eye Microsurgery State Institution
Last refreshed: 23 April 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04995926.

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