NCT04993378

Prospectively Predict the Efficacy of Treatment of Gastrointestinal Tumors Based on Peripheral Multi-omics Liquid Biopsy

Status unknown Last updated 6 August 2021

What this trial tests

trial testing EV-array in Advanced Gastric Adenocarcinoma in 40 participants. Status unknown.

Timeline

1 November 2018

Primary endpoint
30 April 2021

30 July 2021

Quick facts

Lead sponsor	Shen Lin
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	40
Start date	1 November 2018
Primary completion	30 April 2021
Estimated completion	30 July 2021
Sites	1 location across China

Drugs / interventions tested

• EV-array

Conditions studied

• Advanced Gastric Adenocarcinoma — all drugs for Advanced Gastric Adenocarcinoma →
• Immunotherapy — all drugs for Immunotherapy →

Sponsor

Shen Lin — full company profile →

Who can join

18 and older, any sex, with Advanced Gastric Adenocarcinoma or Immunotherapy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To vertify the function of EV-score on predicting \& monitoring immunotherapeutic outcomes of GC

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Plasma extracellular vesicle derived protein profile predicting and monitoring immunotherapeutic outcomes of gastric cancer.
   Zhang C, Chong X, Jiang F, Gao J, et al · · 2022 · cited 39× · PMID 35362262 · DOI 10.1002/jev2.12209
2. Emerging Role of Extracellular Vesicles and Cellular Communication in Metastasis.
   Forder A, Hsing CY, Trejo Vazquez J, Garnis C. · · 2021 · cited 38× · PMID 34943937 · DOI 10.3390/cells10123429
3. ANO1-Mediated Inhibition of Cancer Ferroptosis Confers Immunotherapeutic Resistance through Recruiting Cancer-Associated Fibroblasts.
   Jiang F, Jia K, Chen Y, Ji C, et al · · 2023 · cited 34× · PMID 37341301 · DOI 10.1002/advs.202300881
4. Translational Bioinformatics Applied to the Study of Complex Diseases.
   Casotti MC, Meira DD, Alves LNR, Bessa BGO, et al · · 2023 · cited 12× · PMID 36833346 · DOI 10.3390/genes14020419
5. Unveiling the Potential of Extracellular Vesicles as Biomarkers and Therapeutic Nanotools for Gastrointestinal Diseases.
   Arrè V, Mastrogiacomo R, Balestra F, Serino G, et al · · 2024 · cited 8× · PMID 38675228 · DOI 10.3390/pharmaceutics16040567
6. Hsp70 and Calcitonin Receptor Protein in Extracellular Vesicles from Glioblastoma Multiforme: Biomarkers with Putative Roles in Carcinogenesis and Potential for Differentiating Tumor Types.
   Alberti G, Sánchez-López CM, Marcilla A, Barone R, et al · · 2024 · cited 6× · PMID 38542389 · DOI 10.3390/ijms25063415
7. Extracellular Vesicles in cancer: from isolation and characterization to metastasis, drug resistance, and clinical applications.
   Jurj A, Paul D, Calin GA. · · 2025 · cited 4× · PMID 40629268 · DOI 10.1186/s12885-025-14375-7
8. Current trends in theranostic applications of extracellular vesicles in cancer.
   Almasry Y, Mustafa F, Alfuwais M, AlNachef S, et al · · 2025 · cited 3× · PMID 40530018 · DOI 10.3389/fonc.2025.1592006