NCT04992650 is a NA clinical trial of Fat grafting in Breast Reconstruction, sponsored by Mayo Clinic.

Who is sponsoring NCT04992650?

NCT04992650 is sponsored by Mayo Clinic.

What drugs are being tested in NCT04992650?

Interventions in NCT04992650: Fat grafting.

What condition does NCT04992650 study?

NCT04992650 studies Breast Reconstruction, Radiation Dermatitis, Radiation Fibrosis, Fat Grafting.

Is NCT04992650 still recruiting?

NCT04992650 is currently enrolling by invitation. Last updated 17 December 2025.

Last reviewed 2025-12-17 · How we verify

NCT04992650

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ultrasonic Perfusion Imaging in Post-mastectomy Irradiated Patients

ENROLLING BY INVITATION NA Last updated 17 December 2025

What this trial tests

NA trial testing Fat grafting in Breast Reconstruction in 15 participants. Enrolling by invitation.

Timeline

1 March 2021

Primary endpoint
15 August 2026

15 August 2026

Quick facts

Lead sponsor	Mayo Clinic
Phase	NA
Status	ENROLLING BY INVITATION
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	diagnostic
Enrollment	15
Start date	1 March 2021
Primary completion	15 August 2026
Estimated completion	15 August 2026
Sites	1 location across United States

Drugs / interventions tested

Fat grafting

Conditions studied

Breast Reconstruction — all drugs for Breast Reconstruction →
Radiation Dermatitis — all drugs for Radiation Dermatitis →
Radiation Fibrosis — all drugs for Radiation Fibrosis →
Fat Grafting — all drugs for Fat Grafting →

Sponsor

Mayo Clinic

Who can join

18 and older, female only, with Breast Reconstruction or Radiation Dermatitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to evaluate post-mastectomy breast skin blood supply (perfusion) after radiation therapy, and before and after fat grafting to the breast(s).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The Effects of Radiotherapy on the Sequence and Eligibility of Breast Reconstruction: Current Evidence and Controversy.
Campbell AR, Didier AJ, Sheikh TM, Ansari S, et al · · 2024 · cited 4× · PMID 39272797 · DOI 10.3390/cancers16172939

Verify or expand the search:

Other trials of Fat grafting

Trials testing the same drug.

NCT05985265 — Nano Fat Injection With or Without Fractional Carbon Dioxide Laser in Acne Scars · NA · unknown
NCT03981718 — Adipose-Induced Regeneration of Breast Skin to Treat Post-Mastectomy Radiation Injury in Breast Cancer Patients · NA · withdrawn
NCT03584061 — Treatment of Chronic Postherpetic Pain With Fat Grafting · NA · completed
NCT03085550 — Platelet Rich Plasma and Autologous Fat Graft for Diabetic Ulcer · NA · completed

Other recruiting trials for Breast Reconstruction

Currently open trials in the same condition.

NCT07230535 — Evaluation of Wellbeing and Patient Reported Outcomes After Open vs Robotic Mastectomy With DIEP Reconstruction · NA · recruiting
NCT07293052 — Comparison of Outcome Between Grisotti Flap Versus Reverse Mirror Grisotti Flap for Central Quadrant Breast Tumors · NA · active not recruiting
NCT07331753 — The Outcomes of Fat Grafting Combined With Latissimus Dorsi Muscle Flap for Delayed Breast Reconstruction After Mastecto · NA · recruiting
NCT07185334 — Single-Stage Prepectoral Placement of Textured Implants Using a Polyester Mesh Endoprostheses With Fluoropolymer Coating · NA · active not recruiting
NCT06993714 — 3D-printed Biodegradable Breast Implants for Breast Restoration · Phase 2 · recruiting

Other Mayo Clinic trials

Trials by the same sponsor.

NCT07126548 — A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men · NA · not yet recruiting
NCT07221656 — Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration · not yet recruiting
NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04992650 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
Last refreshed: 17 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04992650.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing