Who is sponsoring NCT04988321?

NCT04988321 is sponsored by Virginia Commonwealth University.

What drugs are being tested in NCT04988321?

Interventions in NCT04988321: Prolonged continuous theta burst stimulation (pcTBS).

What condition does NCT04988321 study?

NCT04988321 studies Diabetic Neuropathy, Painful.

Is NCT04988321 still recruiting?

NCT04988321 is currently completed. Last updated 22 June 2022.

Last reviewed 2022-06-22 · How we verify

NCT04988321

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Theta Burst Brain Stimulation in Diabetic Neuropathy Patients With Neuropathic Pain: Investigating Neural Mechanisms

Completed NA Last updated 22 June 2022

What this trial tests

NA trial testing Prolonged continuous theta burst stimulation (pcTBS) in Diabetic Neuropathy, Painful in 49 participants. Completed in 16 June 2022.

Timeline

3 September 2021

Primary endpoint
16 June 2022

16 June 2022

Quick facts

Lead sponsor	Virginia Commonwealth University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	basic science
Enrollment	49
Start date	3 September 2021
Primary completion	16 June 2022
Estimated completion	16 June 2022
Sites	1 location across United States

Drugs / interventions tested

Prolonged continuous theta burst stimulation (pcTBS)

Conditions studied

Diabetic Neuropathy, Painful — all drugs for Diabetic Neuropathy, Painful →

Sponsor

Virginia Commonwealth University

Who can join

Adults 18 to 75, any sex, with Diabetic Neuropathy, Painful. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of the study is to determine the effects of a newer form of non-invasive brain stimulation (called transcranial magnetic stimulation or TMS) as a treatment in patients with painful diabetic neuropathy to examine its effects on their understanding of their pain experience.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Prolonged continuous theta burst stimulation increases motor corticospinal excitability and intracortical inhibition in patients with neuropathic pain: An exploratory, single-blinded, randomized controlled trial.
Thakkar B, Peterson CL, Acevedo EO. · · 2023 · cited 10× · PMID 37659135 · DOI 10.1016/j.neucli.2023.102894
Single Session Effects of Prolonged Continuous Theta Burst Stimulation Targeting Two Brain Regions on Pain Perception in Patients with Painful Diabetic Neuropathy: A Preliminary Study.
Thakkar B, Peterson CL, Acevedo EO. · · 2024 · cited 5× · PMID 38538225 · DOI 10.31083/j.jin2303054

Verify or expand the search:

Other recruiting trials for Diabetic Neuropathy, Painful

Currently open trials in the same condition.

NCT05623111 — Perineural Injections of Incobotulinumtoxin-A for Diabetic Neuropathic Pain of the Lower Extremities · Phase 2 · recruiting

Other Virginia Commonwealth University trials

Trials by the same sponsor.

NCT05936931 — Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening · NA · not yet recruiting
NCT07365839 — Cemiplimab +/- Fianlimab Post Y90 Radioembolization in Patients With Hepatocellular Carcinoma · Phase 1 · not yet recruiting
NCT07178158 — Enhancing Addiction Treatment Through Psychoeducation · NA · not yet recruiting
NCT07531316 — Safety and Tolerability Study of VVZ-2471 in Healthy Volunteers · Phase 1 · not yet recruiting
NCT07426913 — Cardiovascular Health Education Via Virtual Reality for Breast Cancer Survivors Receiving Anthracyclines or Trastuzumab · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04988321 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Virginia Commonwealth University
Last refreshed: 22 June 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04988321.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing