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NCT04981821: GO-EXCAP2
A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms
NA trial testing GO-EXCAP Mobile App in Cancer in 170 participants. Currently enrolling.
30 June 2026
Quick facts
| Lead sponsor | University of Rochester |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 170 |
| Start date | 3 January 2022 |
| Primary completion | 30 June 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- GO-EXCAP Mobile App
- Behavioral Placebo Control
Conditions studied
- Cancer — all drugs for Cancer →
- Myeloid Neoplasm — all drugs for Myeloid Neoplasm →
Sponsor
University of Rochester
Who can join
60 and older, any sex, with Cancer or Myeloid Neoplasm. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a phase 2 randomized controlled trial (RCT) to assess the preliminary efficacy of the a mobile health exercise intervention (GO-EXCAP) versus a chemotherapy education control in 100 older patients with MN receiving outpatient chemotherapy on physical function and patient-reported outcomes (fatigue, mood, and quality of life). We will also explore the effect of the intervention on TNFα and related cytokine gene promoter methylation and their gene and protein expression.
Publications & conference data
7 peer-reviewed publications reference this trial (live from Europe PMC):
-
A single-arm pilot study of a mobile health exercise intervention (GO-EXCAP) in older patients with myeloid neoplasms.
Loh KP, Sanapala C, Watson EE, Jensen-Battaglia M, et al · · 2022 · cited 28× · PMID 35320340 · DOI 10.1182/bloodadvances.2022007056 -
Exercise and epigenetic ages in older adults with myeloid malignancies.
Loh KP, Sanapala C, Jensen-Battaglia M, Rana A, et al · · 2023 · cited 13× · PMID 37254221 · DOI 10.1186/s40001-023-01145-z -
Protocol for a pilot randomized controlled trial of a mobile health exercise intervention for older patients with myeloid neoplasms (GO-EXCAP 2).
Loh KP, Sanapala C, Janelsins M, Klepin HD, et al · · 2022 · cited 6× · PMID 34949540 · DOI 10.1016/j.jgo.2021.12.011 -
Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies.
Loh KP, Wang Y, Sanapala C, Gilmore N, et al · · 2024 · cited 3× · PMID 38266886 · DOI 10.1016/j.exger.2024.112364 -
Changes in muscle performance among older adults with myeloid malignancies engaging in a mobile health (mHealth) exercise intervention: a single arm pilot study.
Jensen-Battaglia M, Lin PJ, Sanapala C, Watson EE, et al · · 2025 · cited 2× · PMID 39789445 · DOI 10.1186/s12877-024-05668-w -
In-person and virtual assessment of short physical performance battery test in older adults with myeloid malignancies.
Sanapala C, Jensen-Battaglia M, Watson EE, Konatham S, et al · · 2023 · cited 1× · PMID 36790922 · DOI 10.1182/bloodadvances.2022009396 -
Gait Changes After a Mobile Health Exercise Intervention in Older Adults With Myeloid Neoplasms: Single-Arm Pilot Trial.
Wang Y, Jensen-Battaglia M, Lin PJ, Kleckner I, et al · · 2026 · PMID 42054674 · DOI 10.2196/80909
Verify or expand the search:
- PubMed search for NCT04981821
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04981821 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Rochester
- Last refreshed: 3 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04981821.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing