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NCT04980625
Safety and Efficacy of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis for Acute Ischemic Stroke
Completed
NA
Last updated 14 May 2024
What this trial tests
NA trial testing Remote ischemic conditioning in Acute Ischemic Stroke in 558 participants. Completed in 11 May 2023.
Timeline
1 July 2021
Primary endpoint
11 May 2023
11 May 2023
11 May 2023
Quick facts
| Lead sponsor | Yi Yang |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 558 |
| Start date | 1 July 2021 |
| Primary completion | 11 May 2023 |
| Estimated completion | 11 May 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- Remote ischemic conditioning
- Sham remote ischemic conditioning
Conditions studied
- Acute Ischemic Stroke — all drugs for Acute Ischemic Stroke →
Sponsor
Yi Yang — full company profile →
Who can join
18 and older, any sex, with Acute Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to determine the efficacy and safety of remote ischemic conditioning combined with intravenous thrombolysis in treating acute ischemic stroke.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2/HO-1 pathway in MCAO mice.
Sun YY, Zhu HJ, Zhao RY, Zhou SY, et al · · 2023 · cited 175× · PMID 37598463 · DOI 10.1016/j.redox.2023.102852 -
Remote ischemic conditioning after stroke: Research progress in clinical study.
Jiang B, Wang X, Ma J, Fayyaz A, et al · · 2024 · cited 10× · PMID 37927203 · DOI 10.1111/cns.14507 -
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Intravenous Thrombolysis: The SERIC-IVT Trial.
Guo ZN, Abuduxukuer R, Zhang P, Qu Y, et al · · 2025 · cited 8× · PMID 39772709 · DOI 10.1161/strokeaha.124.048509 -
Randomized Secondary Prevention Trials in Participants With Symptomatic Intracranial Atherosclerotic Stenosis.
Dunn LE, Wang Y, Kass-Hout T, Chiu D. · · 2024 · cited 8× · PMID 38252760 · DOI 10.1161/strokeaha.123.043632 -
Multi-Target and Multi-Phase Adjunctive Cerebral Protection for Acute Ischemic Stroke in the Reperfusion Era.
Zhao M, Wang J, Liu G, Li S, et al · · 2024 · cited 6× · PMID 39334947 · DOI 10.3390/biom14091181 -
Multimodal Neuroprotection in Ischemic Stroke: Emerging Non-Pharmacological Interventions from Bench to Bedside.
Cui J, Yang J, Liu L, Liu X, et al · · 2025 · PMID 41154205 · DOI 10.3390/brainsci15101111
Verify or expand the search:
- PubMed search for NCT04980625
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Remote ischemic conditioning
Trials testing the same drug.
- NCT03484936 — Safety and Efficacy of Remote Ischemic Conditioning in Patients With Spontaneous Intracerebral Hemorrhage · NA · not yet recruiting
- NCT07412249 — Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis · NA · recruiting
- NCT03669653 — Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Ischemic Stroke · NA · not yet recruiting
- NCT06702644 — Safety and Efficacy of Remote Ischemic Conditioning in Patients with Chronic Internal Carotid Artery Occlusion Receiving · NA · not yet recruiting
- NCT06171334 — Remote Ischemic Conditioning in PPMS · NA · not yet recruiting
Other recruiting trials for Acute Ischemic Stroke
Currently open trials in the same condition.
- NCT07115940 — Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours · NA · recruiting
- NCT07404852 — Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemi · NA · recruiting
- NCT07361302 — A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Pe · Phase 3 · recruiting
- NCT07436156 — SUMMIT RISE Study of Acute Ischemic Stroke Patients · Phase 4 · recruiting
- NCT07203625 — Tenecteplase Before Interhospital Transfer in Acute Basilar Artery Occlusion at 4.5 to 24 Hours · Phase 4 · recruiting
Other Yi Yang trials
Trials by the same sponsor.
- NCT03484936 — Safety and Efficacy of Remote Ischemic Conditioning in Patients With Spontaneous Intracerebral Hemorrhage · NA · not yet recruiting
- NCT07042490 — Efficacy and Safety of Plasma Adsorption Combined With EVT for AIS-LVO · NA · not yet recruiting
- NCT03669653 — Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Ischemic Stroke · NA · not yet recruiting
- NCT05743101 — Safety and Efficacy Study of Levofloxacin Combined With Endovascular Thrombectomy for Acute Ischemic Stroke · NA · not yet recruiting
- NCT06941961 — iTBS for Acute Ischemic Stroke After Thrombectomy · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT04980625 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Yi Yang
- Last refreshed: 14 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04980625.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing