NCT04977843

Effect of E-BAL on Severity of VAP Assessed Through CPIS on the Patients of Traumatic Brain Injury in Neurocritical Care, Also Effect on Days of Ventilation and ICU Stay.

Status unknown NA Last updated 27 July 2021

What this trial tests

NA trial testing EARLY BRONCHOALVEOLAR LAVAGE in Traumatic Brain Injury in 60 participants. Status unknown.

Timeline

1 June 2021

Primary endpoint
30 December 2021

30 December 2021

Quick facts

Lead sponsor	Jinnah Hospital
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	60
Start date	1 June 2021
Primary completion	30 December 2021
Estimated completion	30 December 2021
Sites	1 location across Pakistan

Drugs / interventions tested

• EARLY BRONCHOALVEOLAR LAVAGE

Conditions studied

• Traumatic Brain Injury — all drugs for Traumatic Brain Injury →
• Ventilator Associated Pneumonia — all drugs for Ventilator Associated Pneumonia →

Sponsor

Jinnah Hospital

Who can join

Adults 15 to 60, any sex, with Traumatic Brain Injury or Ventilator Associated Pneumonia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Severe traumatic brain injury (STBI) is a leading cause of disability, mortality, and economic burden worldwide. The impact of severe traumatic brain injury (STBI) on the economy of developing countries like Pakistan is distressing. Pakistan has a large proportion of the young adult population in the World. Motorbike is the most common locomotive vehicle. These young ones are in the economically productive part of their lives. Their loss is an economical set back not only for their families but also for the Nation. Patients with STBI need standardized management in Neuro-critical care unit (NCCU). Although the setup and maintenance cost of an effective NCCU is one of the major burden on the budget of any public sector hospital, but the young survivor in turn can be productive for the Nation.

During mechanical ventilation, severe traumatic brain injury patients frequently develop ventilator-associated pneumonia (VAP). Ventilator-associated pneumonia can be evaluated using Clinical pulmonary infection score (CPIS). CPIS is considered as an important clinical indicator of pneumonia in NCCU.

Bronchoalveolar Lavage (BAL) is a minimally invasive procedure done with instillation of normal saline into subsegments of the lung followed by suction and collection of the instilled fluid for analysis with flexible bronchoscope. Patients with moderate and severe traumatic brain injury usually present with altered conscious level, and most of them already have aspiration of vomitus, debris and secretions which increase the risk of VAP in them. Bronchoalveolar lavage can be helpful in preventing this dreadful VAP by clearing the airways.

The aim of this study is to find out the effect of early Bronchoalveolar Lavage on severity of development of VAP assessed through clinical pulmonary infection score (CPIS) in TBI patients.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.