Last reviewed · How we verify
NCT04975906
The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis
trial in Metabolic Acidosis in 16,475 participants. Completed in 6 June 2023.
31 December 2021
Quick facts
| Lead sponsor | Changi General Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 16,475 |
| Start date | 1 July 2017 |
| Primary completion | 31 December 2021 |
| Estimated completion | 6 June 2023 |
| Sites | 1 location across Singapore |
Conditions studied
- Metabolic Acidosis — all drugs for Metabolic Acidosis →
- Critical Illness — all drugs for Critical Illness →
- Anion Gap Acidosis — all drugs for Anion Gap Acidosis →
- Lactic Acidosis — all drugs for Lactic Acidosis →
Sponsor
Changi General Hospital
Who can join
Eligibility, any sex, with Metabolic Acidosis or Critical Illness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Background: The serum anion gap (AG) is commonly used as a screening tool for acid-base disorders. With modern laboratory techniques using ion-selective electrodes to measure the main electrolyte components of the AG, our definition high AG (HAGMA) should be reviewed. Aim: This study aims to assess the diagnostic value of AG and to determine a diagnostic threshold for HAGMA in a high-prevalence clinical setting. Method: Computerized extraction of anonymised data from electronic medical records was performed. A pre-defined criteria included all inpatients of an acute-care hospital who had measurements for organic acids (lactate, ketone or salicylate) paired with a serum urea, electrolyte and creatinine panel.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04975906
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Changi General Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04975906 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Changi General Hospital
- Last refreshed: 15 June 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04975906.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing