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NCT04973787: MicroSpA & RA
The Role of Microbiome on Biological Therapy Efficacy in axSpA and RA
trial testing biological disease-modifying antirheumatic drugs (bDMARDs) in Axial Spondyloarthritis in 90 participants. Status unknown.
31 January 2022
Quick facts
| Lead sponsor | Universidade Nova de Lisboa |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 90 |
| Start date | 1 August 2020 |
| Primary completion | 31 January 2022 |
| Estimated completion | 31 January 2022 |
| Sites | 10 locations across Portugal |
Drugs / interventions tested
- biological disease-modifying antirheumatic drugs (bDMARDs) — full drug profile →
Conditions studied
- Axial Spondyloarthritis — all drugs for Axial Spondyloarthritis →
- Arthritis, Rheumatoid — all drugs for Arthritis, Rheumatoid →
Sponsor
Universidade Nova de Lisboa — full company profile →
Who can join
Adults 18 to 65, any sex, with Axial Spondyloarthritis or Arthritis, Rheumatoid. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Spondyloarthritis (SpA) and Rheumatoid arthritis (RA) are among the most common chronic inflammatory rheumatic diseases. Introduction of Tumor Necrosis Factor alpha inhibitors (TNFi) to the therapeutic strategy improved acute inflammation and pain, but a significant percentage of patients develop severe adverse events or are still non responders or incomplete responders to these expensive treatments. There is an urgent need to identify new predictors of biological therapy response. It has been described the role of microbiota in some rheumatic diseases, however, clinical trials are scarce. We hypothesized that microbiota or their metabolites may play a role in therapeutic response to TNFi.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04973787
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Universidade Nova de Lisboa trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04973787 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidade Nova de Lisboa
- Last refreshed: 22 July 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04973787.
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