NCT04972383 is a Phase 3 clinical trial of Platelet Rich Plasma in Knee Osteoarthritis, sponsored by Kaohsiung Medical University Chung-Ho Memorial Hospital.

Who is sponsoring NCT04972383?

NCT04972383 is sponsored by Kaohsiung Medical University Chung-Ho Memorial Hospital.

What drugs are being tested in NCT04972383?

Interventions in NCT04972383: Platelet Rich Plasma, Hyaluronic Acid.

What condition does NCT04972383 study?

NCT04972383 studies Knee Osteoarthritis.

Is NCT04972383 still recruiting?

NCT04972383 is currently completed. Last updated 10 October 2023.

Last reviewed 2023-10-10 · How we verify

NCT04972383

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparing Effect of Autologous Platelet-Rich Plasma Versus Hyaluronic Acid Treatment on Knee Osteoarthritis

Completed Phase 3 Last updated 10 October 2023

What this trial tests

Phase 3 trial testing Platelet Rich Plasma in Knee Osteoarthritis in 116 participants. Completed in 16 October 2019.

Timeline

7 November 2017

Primary endpoint
16 October 2019

16 October 2019

Quick facts

Lead sponsor	Kaohsiung Medical University Chung-Ho Memorial Hospital
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	116
Start date	7 November 2017
Primary completion	16 October 2019
Estimated completion	16 October 2019
Sites	1 location across Taiwan

Drugs / interventions tested

Platelet Rich Plasma — full drug profile →
Hyaluronic Acid (HYALURONIC ACID) — full drug profile →

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

Kaohsiung Medical University Chung-Ho Memorial Hospital

Who can join

Adults 50 to 85, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To compare the efficacy and structural change of intraarticular single platelet-rich plasma(PRP) versus novel crosslinked Hyaluronic Acid(HA)(HyajointPlus) for the treatment of early stage knee osteoarthritis(OA). This was a prospective, double-blind, RCT with an allocation ratio of 1:1.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Comparing the Efficacy of Intra-Articular Single Platelet-Rich Plasma(PRP) versus Novel Crosslinked Hyaluronic Acid for Early-Stage Knee Osteoarthritis: A Prospective, Double-Blind, Randomized Controlled Trial.
Wang YC, Lee CL, Chen YJ, Tien YC, et al · · 2022 · cited 29× · PMID 36013495 · DOI 10.3390/medicina58081028

Verify or expand the search:

Other trials of Platelet Rich Plasma

Trials testing the same drug.

NCT07483320 — Extracorporeal Shockwave Therapy and Platelet-Rich Plasma for Midportion Achilles Tendinopathy · NA · not yet recruiting
NCT07329361 — Efficacy and Safety of Intra-articular Injections of Frozen Platelet-Rich Plasma in Patients With Knee Osteoarthritis · NA · recruiting
NCT05224726 — Platelet Rich Plasma for Uterine Scar · NA · recruiting
NCT06810726 — Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroisc · Phase 2 · recruiting
NCT06769074 — Assessment of Platelet Rich Plasma Injection in Managing Female Patients Complaining of Mixed Urinary Incontinence (PRP) · NA · active not recruiting

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other Kaohsiung Medical University Chung-Ho Memorial Hospital trials

Trials by the same sponsor.

NCT07342426 — High and Low Dose High-intensity Laser Therapy Lateral Epicondylitis · Phase 4 · recruiting
NCT07346469 — Exploring the Effects of Magnesium Ions on Peripheral Neuropathy, Serum Magnesium Ion Concentration,Sleep Quality, and Q · NA · not yet recruiting
NCT07154407 — AI-assisted Masticatory Muscle Training in Patients With Schizophrenia · NA · not yet recruiting
NCT07154628 — Effect of Topical Lidocaine Spraying on the Vocal Cords Before Intubation During Robotic Surgery: a Randomized Controlle · Phase 4 · not yet recruiting
NCT07126444 — Effects of an Exercise Snack Intervention on Employee Health and Work Performance · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04972383 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Kaohsiung Medical University Chung-Ho Memorial Hospital
Last refreshed: 10 October 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04972383.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing