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NCT04971798
Cell-free Stem Cell-derived Extract Formulation for Knee Osteoarthritis
EARLY_PHASE1 trial testing Cell-free Stem Cell-derived Extract Formulation (CCM) in Osteoarthritis, Knee in 12 participants. Status unknown.
31 December 2025
Quick facts
| Lead sponsor | General Therapeutics |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 12 |
| Start date | 1 January 2023 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
Drugs / interventions tested
- Cell-free Stem Cell-derived Extract Formulation (CCM) — full drug profile →
Conditions studied
- Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →
Sponsor
General Therapeutics — full company profile →
Who can join
18 and older, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to determine the safety and efficacy of intraarticular injection of Cell-free Stem Cell-derived Extract Formulation for treatment of knee osteoarthritis symptoms.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Extracellular vesicles as human therapeutics: A scoping review of the literature.
Fusco C, De Rosa G, Spatocco I, Vitiello E, et al · · 2024 · cited 74× · PMID 38738585 · DOI 10.1002/jev2.12433 -
Cell-free stem cell-derived extract formulation for treatment of knee osteoarthritis: study protocol for a preliminary non-randomized, open-label, multi-center feasibility and safety study.
Gupta A, Maffulli N, Rodriguez HC, Mistovich RJ, et al · · 2021 · cited 19× · PMID 34416898 · DOI 10.1186/s13018-021-02672-3 -
Decoding the therapeutic potential of extracellular vesicles in osteoarthritis: from biomolecular composition to clinical translation.
Cheng W, Jin P, Liu W, Feng R, et al · · 2025 · cited 1× · PMID 41382397 · DOI 10.1097/js9.0000000000003219
Verify or expand the search:
- PubMed search for NCT04971798
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Osteoarthritis, Knee
Currently open trials in the same condition.
- NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
- NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
- NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
- NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
- NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04971798 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by General Therapeutics
- Last refreshed: 21 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04971798.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing