Alcohol Metabolism and Disease Risk in Asians (R21AA28365)

NCT04967599 NA COMPLETED Results posted

The primary pathway of alcohol metabolism involves two main enzymes, alcohol and aldehyde dehydrogenase. Several genes that encode these enzymes have variants that alter the rate of alcohol metabolism and increase levels of acetaldehyde. The variant ALDH2\*2 allele is associated with the flushing response (i.e., Asian glow) and is found almost exclusively in individuals of east Asian descent. Although having variant ALDH2 alleles is protective against heavy drinking and alcohol use disorders, for those who do drink, these variants also are associated with elevations in risk for several health problems. The premise of this study is that we can affect early drinking behavior through personalized communication about these health-related risks.

Details

Lead sponsor	University of Southern California
Phase	NA
Status	COMPLETED
Enrolment	360
Start date	Wed Aug 18 2021 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Wed Jan 18 2023 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Healthy

Interventions

• Phenotype Feedback Intervention
• Genotype Feedback Intervention

Countries

United States