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NCT04965649: TIPHI
Is There an Association Between Innate CD8+ T Cells and the Evolution of Tyrosine Kinase Inhibitor Resistance Mutations in Phi+ Hematological Malignancies.
trial testing Phenotyping of total and innate CD8+T cells by flow cytometry in Leukemia in 30 participants. Status unknown.
1 July 2024
Quick facts
| Lead sponsor | Centre Hospitalier Universitaire de Nīmes |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 1 January 2021 |
| Primary completion | 1 July 2024 |
| Estimated completion | 1 January 2025 |
| Sites | 1 location across France |
Drugs / interventions tested
- Phenotyping of total and innate CD8+T cells by flow cytometry
Conditions studied
- Leukemia — all drugs for Leukemia →
- Myelogenous Leukemia — all drugs for Myelogenous Leukemia →
- Chronic Leukemia — all drugs for Chronic Leukemia →
- BCR-ABL Positive Acute Myeloid Leukemia — all drugs for BCR-ABL Positive Acute Myeloid Leukemia →
Sponsor
Centre Hospitalier Universitaire de Nīmes
Who can join
18 and older, any sex, with Leukemia or Myelogenous Leukemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this project is to test whether low levels of BcrAbl1, despite the presence of resistance mutations, are related to high levels of innate CD8+ T cells, in the hypothesis that these cells have an anti-tumor role. This research aims to investigate: * An association between the rate of innate CD8+ T cells and the evolution of Phi+ pathologies (Chronic Myeloid Leukemia and Philadelphia chromosome-positive Acute lymphocytic leukemia (Phi+ ALL) carrying a resistance mutation, according to the ELN 2013 and Phi LMC recommendations. * An association between the level of innate CD8+ T cells and the expansion of TKI resistance clones, assessed as the number of BcrAbl1 copies carrying the mutation relative to the number of Abl1 copies.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The expanding Pandora's toolbox of CD8<sup>+</sup>T cell: from transcriptional control to metabolic firing.
Wu J, Lu Z, Zhao H, Lu M, et al · · 2023 · cited 6× · PMID 38082437 · DOI 10.1186/s12967-023-04775-3
Verify or expand the search:
- PubMed search for NCT04965649
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04965649 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Universitaire de Nīmes
- Last refreshed: 30 August 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04965649.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing