NCT04963504: DiffLung

Pulmonary Diffusing Capacity During Postural Postural Changes and Acute Exercise

Completed NA Last updated 10 November 2021

What this trial tests

NA trial testing Rest-to-exercise in Clinical Assessments of Pulmonary Diffusing Capacity in 20 participants. Completed in 30 October 2021.

Timeline

12 July 2021

Primary endpoint
30 September 2021

30 October 2021

Quick facts

Lead sponsor	Rigshospitalet, Denmark
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	diagnostic
Enrollment	20
Start date	12 July 2021
Primary completion	30 September 2021
Estimated completion	30 October 2021
Sites	1 location across Denmark

Drugs / interventions tested

• Rest-to-exercise
• Sitting-to-supine

Conditions studied

• Clinical Assessments of Pulmonary Diffusing Capacity — all drugs for Clinical Assessments of Pulmonary Diffusing Capacity →

Sponsor

Rigshospitalet, Denmark

Who can join

18 and older, any sex, with Clinical Assessments of Pulmonary Diffusing Capacity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) has recently been standardised and validated for clinical use. It involves a very short breath-hold time (≤5 seconds), and it may be repeated up to 12 times without affecting measurements, and it is thus ideal for assessing acute changes in pulmonary diffusing capacity and its components during various physiological manoeuvres. The aim of the present study is to compare the test-retest reliability of pulmonary diffusing capacity measurements during postural changes (sitting vs. supine) vs. rest-to-exercise. DLCO/NO will either be measured in the sitting position during rest vs. exercise or in the sitting and supine posture, and this will be repeated within 1-7 days in 20 healthy individuals that will be randomised to one of the two interventions. Statistically,the test-retest relaibility of sitting-to-supine vs. rest-to-exercise changes in DLCO/NO will be compared by parametric methods.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Pulmonary diffusing capacity to nitric oxide and carbon monoxide during exercise and in the supine position: a test-retest reliability study.
   Madsen AC, Thomsen RS, Nymand SB, Hartmann JP, et al · · 2023 · cited 9× · PMID 36621806 · DOI 10.1113/ep090883