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NCT04962074
Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods
NA trial testing Microfluidic sperm sorting chip in Reduced Sperm Motility in 22 participants. Completed in 20 September 2020.
20 September 2020
Quick facts
| Lead sponsor | Maltepe University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 22 |
| Start date | 5 January 2020 |
| Primary completion | 20 September 2020 |
| Estimated completion | 20 September 2020 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Microfluidic sperm sorting chip
- Density gradient
Conditions studied
- Reduced Sperm Motility — all drugs for Reduced Sperm Motility →
- IVF — all drugs for IVF →
- ICSI — all drugs for ICSI →
- Astheno Teratozoospermia — all drugs for Astheno Teratozoospermia →
Sponsor
Maltepe University
Who can join
Eligibility, male only, with Reduced Sperm Motility or IVF. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Purpose: To compare the effects of the density gradient centrifugation and microfluidic chip sperm preparation methods on embryo development in a study population with astheno-teratozoospermia. Materials and Methods: In this prospective study, the semen samples of the patients with astheno-teratozoospermia were divided into two groups for preparation with either the microfluidic or density gradient methods. Selected spermatozoa were used to fertilize the mature sibling oocytes. Semen parameters and embryo development on days 3 and 5 were assessed.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Microfluidics for in vitro fertilization: from science to clinical validation.
Pensabene V, Agate F, Santos Miranda A, Picton HM. · · 2026 · PMID 41349964 · DOI 10.1093/humupd/dmaf028
Verify or expand the search:
- PubMed search for NCT04962074
- Europe PMC full search
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04962074 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Maltepe University
- Last refreshed: 14 July 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04962074.
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