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NCT04961125
Multicenter Study on the Pathogenic Germline Gene Variants of Colorectal Polyposis in China
trial testing germline variants in Colorectal Polyposis in 200 participants. Status unknown.
31 December 2022
Quick facts
| Lead sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 200 |
| Start date | 2 August 2021 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 December 2024 |
| Sites | 5 locations across China |
Drugs / interventions tested
- germline variants
Conditions studied
- Colorectal Polyposis — all drugs for Colorectal Polyposis →
Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Who can join
Eligibility, any sex, with Colorectal Polyposis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients suspected of adenomatous polyposis were included. The criteria used were more than 10 polyps observed under colonoscopy, and pathological confirmation of adenoma. Clinical data and pedigree information were collected. The variants of 139 genes associated with different hereditary cancers and polyposis were screened by NGS, which was performed by Genetron Health on the HiSeqX-ten sequencing platform.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Uncovering the genetic variation spectrum of colorectal polyposis from a multicentre cohort in China.
Yang M, Zhang D, Yuan Z, Chen D, et al · · 2025 · cited 2× · PMID 40089605 · DOI 10.1038/s41698-025-00864-2 -
The Progress of Colorectal Polyposis Syndrome in Chinese Population.
Yuan Z, Yang M, Yuan Y. · · 2023 · cited 2× · PMID 37795462 · DOI 10.1055/s-0043-1767708
Verify or expand the search:
- PubMed search for NCT04961125
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04961125 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Second Affiliated Hospital, School of Medicine, Zhejiang University
- Last refreshed: 15 July 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04961125.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing