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NCT04957355: NMES
Effect of NMES on Balance and Fall Risk in Chronic Stroke
NA trial testing Neuromuscular electrical stimulation (NMES) or Functional electrical stimulation (FES) in Chronic Stroke in 20 participants. Currently enrolling.
31 August 2025
Quick facts
| Lead sponsor | University of Illinois at Chicago |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 15 May 2021 |
| Primary completion | 31 August 2025 |
| Estimated completion | 30 November 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Neuromuscular electrical stimulation (NMES) or Functional electrical stimulation (FES)
Conditions studied
- Chronic Stroke — all drugs for Chronic Stroke →
Sponsor
University of Illinois at Chicago
Who can join
Adults 18 to 90, any sex, with Chronic Stroke. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is to describe the effect of neuromuscular electrical stimulation (NMES) in the form of functional electrical stimulation (FES) applied to different lower limb muscles on reactive balance and gait performance in stroke participants. Methods: Twenty individuals with chronic stroke will be asked to perform an experimental protocol that includes a postural disturbance in the form of a slip- or trip-like perturbation and a standardized walking test in both laboratory and outdoor environments with and without FES applied to different lower limb muscles of the paretic leg. FES will be applied using an advanced software that is able to synchronize muscle activation with the time of perturbation onset and according to the phases of gait. This project design aims to examine whether a specific pattern of lower limb muscle stimulation could improve the kinematic and behavioral responses during reactive balance following slip- and trip-like perturbations. Additionally, the project aims to see if the kinematic and spatio-temporal gait parameters can be modified during a standardized walking test under different sensory and environmental conditions.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Functional electrical stimulation to enhance reactive balance among people with hemiparetic stroke.
Purohit R, Varas-Diaz G, Bhatt T. · · 2024 · cited 3× · PMID 38214733 · DOI 10.1007/s00221-023-06729-z
Verify or expand the search:
- PubMed search for NCT04957355
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04957355 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Illinois at Chicago
- Last refreshed: 27 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04957355.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing