NCT04956952 is a NA clinical trial of EECP in Single-ventricle, sponsored by Boston Children's Hospital.

Who is sponsoring NCT04956952?

NCT04956952 is sponsored by Boston Children's Hospital.

What drugs are being tested in NCT04956952?

Interventions in NCT04956952: EECP.

What condition does NCT04956952 study?

NCT04956952 studies Single-ventricle, Congenital Heart Disease.

Is NCT04956952 still recruiting?

NCT04956952 is currently completed. Last updated 13 June 2023.

Last reviewed 2023-06-13 · How we verify

NCT04956952

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Enhanced External Counterpulsation in Patients With Fontan Circulation

Completed NA Last updated 13 June 2023

What this trial tests

NA trial testing EECP in Single-ventricle in 23 participants. Completed in 17 May 2023.

Timeline

31 March 2022

Primary endpoint
17 May 2023

17 May 2023

Quick facts

Lead sponsor	Boston Children's Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	23
Start date	31 March 2022
Primary completion	17 May 2023
Estimated completion	17 May 2023
Sites	1 location across United States

Drugs / interventions tested

EECP

Conditions studied

Single-ventricle — all drugs for Single-ventricle →
Congenital Heart Disease — all drugs for Congenital Heart Disease →

Sponsor

Boston Children's Hospital

Who can join

18 and older, any sex, with Single-ventricle or Congenital Heart Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of the proposed study is to determine the safety of enhanced external counterpulsation (EECP), a system for compressing the blood vessels in the legs in synchrony with an individual's cardiac rhythm, in clinically well, adult Fontan patients, to document the acute hemodynamic and myocardial effects of EECP on the Fontan circulation, and to demonstrate acute changes in endothelial function after one hour of the procedure.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Acute Effects of Enhanced External Counterpulsation in Adults With Fontan Circulation.
Wu FM, Misra A, Valle CW, Duncan ME, et al · · 2025 · PMID 39983607 · DOI 10.1016/j.jacadv.2025.101591

Verify or expand the search:

Other trials of EECP

Trials testing the same drug.

NCT06227286 — Enhanced External Counter Pulsation on Afterload Mismatch Rate in Post-TEER (PAMPER) · NA · not yet recruiting
NCT03102502 — Impact of Enhanced External Counterpulsation on Vascular Hemodynamics and Status · NA · completed

Other recruiting trials for Single-ventricle

Currently open trials in the same condition.

NCT07073612 — Transcatheter Fontan Stenting: Impact on Hepatic Stiffness and Exercise Capacity · recruiting
NCT06434207 — Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis · recruiting
NCT06613477 — PK/PD of Digoxin in Infants With SVHD · Phase 1, PHASE2 · recruiting
NCT06538571 — Association of Near Infrared Spectroscopy With Interstage Outcomes · NA · recruiting
NCT06150950 — REHAB Fontan Failure: A Trial of Cardiac Rehabilitation · NA · recruiting

Other Boston Children's Hospital trials

Trials by the same sponsor.

NCT06804382 — Academic Detailing to Optimize PrEP Implementation in Pediatric Primary Care Settings: ADOPT-PrEP · NA · not yet recruiting
NCT05113394 — Preventing Childhood Asthma Using Prophylactic House Dust Mite Allergen Immunotherapy · Phase 2 · withdrawn
NCT06434220 — Effect of Predictive Model on ED Physician Assessments of Patient Disposition · NA · not yet recruiting
NCT07476430 — Readiness Outcomes Affecting Return to Sport 3.0 · NA · not yet recruiting
NCT06706336 — Radon Asthma Intervention Trial · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04956952 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Boston Children's Hospital
Last refreshed: 13 June 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04956952.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing