HIV-1, Insufficient Sleep and Vascular Endothelial Dysfunction

NCT04956861 NA COMPLETED Results posted

The investigators hypothesize that chronic insufficient sleep is associated with diminished endothelium-dependent nitric oxide-mediated vasodilation and tissue-type plasminogen activator release in anti-retroviral (ART)-treated HIV-1-seropositive adults. Furthermore, the investigators hypothesize that the postulated diminishment in endothelial vasodilator and fibrinolytic function with insufficient sleep will be due, at least in part, to increased oxidative stress. Moreover, increasing sleep duration and improving sleep quality will increase both endothelium-dependent nitric oxide-mediated vasodilation and endothelial tissue-type plasminogen activator release in ART-treated HIV-1-seropositive adults. Increases in endothelial vasodilator and fibrinolytic function will be due, at least in part, to reduced oxidative stress.

Details

Lead sponsor	University of Colorado, Boulder
Phase	NA
Status	COMPLETED
Enrolment	88
Start date	Thu Dec 17 2015 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Fri Aug 07 2020 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• HIV-1

Interventions

• Individualized Targeted Sleep

Countries

United States