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NCT04956211
Periodontal Treatment and Ischemic Stroke
NA trial testing Periodontal therapy in Stroke, Ischemic in 60 participants. Status unknown.
11 November 2022
Quick facts
| Lead sponsor | University of Santiago de Compostela |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 29 September 2021 |
| Primary completion | 11 November 2022 |
| Estimated completion | 29 December 2023 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Periodontal therapy
Conditions studied
- Stroke, Ischemic — all drugs for Stroke, Ischemic →
- Periodontitis — all drugs for Periodontitis →
Sponsor
University of Santiago de Compostela
Who can join
18 and older, any sex, with Stroke, Ischemic or Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A bulk of observational evidence suggests an association between periodontitis and recurrent vascular events in ischemic stroke survivors. One plausible biological mechanism relies on the systemic inflammatory response posed by periodontitis together with changes in the normal function of the vascular endothelium which might lead to recurrence in these population. A non-pharmacological anti-inflammatory treatment (non-surgical periodontal therapy) has shown to reduce systemic inflammatory markers and improve endothelial function. Therefore, we propose to carry out a 1-year follow-up pilot randomized controlled clinical trial to investigate whether control of local and systemic inflammation as well as improve function of the vascular endothelium can lead to reduce the risk of recurrence in patients diagnosed from ischemic stroke.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis.
Ye Z, Cao Y, Miao C, Liu W, et al · · 2022 · cited 13× · PMID 36194420 · DOI 10.1002/14651858.cd009197.pub5
Verify or expand the search:
- PubMed search for NCT04956211
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other University of Santiago de Compostela trials
Trials by the same sponsor.
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- NCT07430748 — REGENFAST vs L-PRF in Periodontal Regeneration · EARLY_PHASE1 · active not recruiting
- NCT07355673 — The Influence of Isolation Techniques in Gingival Irritation During an In-office Bleaching · NA · completed
- NCT07355647 — Efficacy of a Desensitizing Agent During In-Office Bleaching · EARLY_PHASE1 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04956211 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Santiago de Compostela
- Last refreshed: 30 September 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04956211.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing