Last reviewed · How we verify
NCT04956198
Drug Sensitivity and Mutation Profiling
trial in Ewing Sarcoma in 14 participants. Completed in 31 December 2022.
31 December 2022
Quick facts
| Lead sponsor | Florida International University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 14 |
| Start date | 17 November 2020 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 December 2022 |
| Sites | 1 location across United States |
Conditions studied
- Ewing Sarcoma — all drugs for Ewing Sarcoma →
- Osteosarcoma — all drugs for Osteosarcoma →
- Rhabdomyosarcoma — all drugs for Rhabdomyosarcoma →
- Wilms Tumor — all drugs for Wilms Tumor →
Sponsor
Florida International University
Who can join
Under 21, any sex, with Ewing Sarcoma or Osteosarcoma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is a prospective, non-randomized observational study. Freshly isolated tumor cells will be tested for chemosensitivity to the standard of care drugs as single agents and in combinations using state-of-the-art viability assay designed for ex-vivo high-throughput drug sensitivity testing (DST). In addition, the genetic profile of the tumor will be obtained from the medical records and correlated with drug response.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Functional personalized complex combination nano therapy for osteosarcoma.
Bar-Natan O, Harris Y, Sason H, Shamay Y. · · 2025 · cited 2× · PMID 41102354 · DOI 10.1038/s41598-025-20222-3
Verify or expand the search:
- PubMed search for NCT04956198
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Ewing Sarcoma
Currently open trials in the same condition.
- NCT07297979 — Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS) · Phase 1 · recruiting
- NCT07222735 — Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcoma · Phase 1 · recruiting
- NCT07197554 — A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies · Phase 1 · recruiting
- NCT07188532 — Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial · NA · recruiting
- NCT07141862 — Fertility Preservation in Children With Solid Tumors: Detection of Residual Disease by a Sensitive Method · recruiting
Other Florida International University trials
Trials by the same sponsor.
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- NCT06489314 — Mental Health Treatment to Improve Father Depression and Child Outcomes in Kenya · NA · enrolling by invitation
- NCT07199361 — Uncovering the Mechanism of Pain Relief by Peripheral Transcutaneous Magnetic Stimulation · NA · recruiting
- NCT04571502 — Integration of Health Information Technology and Promotion of Personhood in Family-Centered Dementia Care · NA · enrolling by invitation
- NCT06637436 — PrEP Readiness Interventions for Sustained Motivation (PRISM) · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04956198 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Florida International University
- Last refreshed: 14 February 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04956198.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing