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Short Term, High Dose Vitamin D Supplementation in Moderate to Severe COVID-19 Disease (SHADE-S)
COVID-19 caused by SARS-CoV-2 virus has affected the lives of millions of individuals globally and also severely strained the medical community. Pre-symptomatic and asymptomatic SARS-CoV-2 positive individuals far outnumber the symptomatic ones or those with severe disease. The transmission potential of SARS CoV-2 is potentially greater than earlier viral outbreaks of SARS-CoV and MERS-CoV.Routine measures of social distancing, personal hand hygiene and limited outdoor contact activities have shown benefits to limit corona virus infection. However, the role of vitamin D in SARS-CoV-2 infection is sparingly explored despite the knowledge of an immunomodulatory role and protective effect of vitamin D against viral infections. Meta-analysis of five clinical trials of vitamin D supplementation found that those receiving vitamin D supplementation had fewer respiratory tract infections (odds ratio = 0.58 (95%CI, 0.42 - 0.81).Any immune-modulatory effect of vitamin D is likely to be observed at levels which are considered higher than that required for normal bone metabolism.
Details
| Lead sponsor | Post Graduate Institute of Medical Education and Research, Chandigarh |
|---|---|
| Phase | PHASE4 |
| Status | COMPLETED |
| Enrolment | 90 |
| Start date | Sun Aug 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Dec 10 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Covid19
Interventions
- cholecalciferol 6 lakh IU
Countries
India