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NCT04950881
Cervical Vagus Nerve Block Prevents Ocularvagal Reflex
NA trial testing Ultrasound guided vagus nerve block in Reflex, Oculocardiac in 60 participants. Status unknown.
31 December 2022
Quick facts
| Lead sponsor | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 60 |
| Start date | 1 July 2021 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 March 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- Ultrasound guided vagus nerve block
- Bradycardia Treatment — full drug profile →
Conditions studied
- Reflex, Oculocardiac — all drugs for Reflex, Oculocardiac →
Sponsor
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Who can join
Adults 16 to 70, any sex, with Reflex, Oculocardiac. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In ophthalmic surgery, surgical operations such as pulling certain eye tissues or compressing the eyeball often leads to bradycardia, arrhythmia even cardiac arrest, bradypnea, nausea and vomiting and elevated blood sugar level. The condition is called the ocularvagal reflex (OVR). Traditionally, when the bradycardia or arrhythmia happens, the operation has to be suspended, and atropine or isoproterenol is given intravenously to treat the bradycardia. Vagus nerve block may be an effective way to prevent and alleviate this vagal reflex. However it is difficult to perform the nerve block with anatomical landmark (blind) methods. In this study, the investigators used ultrasound-guided right cervical vagus nerve block to reduce the incidence of the OVR. The researchers hypothesized that low concentrations of lidocaine or ropivacaine can block the right cervical vagus nerve and reduce the incidence of intraoperative OVR. Researchers evaluated the changes of heart rate, blood pressure, oxygen saturation, and airway pressure in patients undergoing high-risk OVR surgery.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The Median Effective Concentration of Lidocaine for ultrasound-guided cervical vagus nerve block to prevent oculocardiac reflex in ocular Surgery: a double-blind randomised trial
Zhang Q, Zhang J, Wang P, Tan N, et al · · 2026 · DOI 10.21203/rs.3.rs-8693077/v1
Verify or expand the search:
- PubMed search for NCT04950881
- Europe PMC full search
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04950881 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- Last refreshed: 21 February 2022
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