Last reviewed · How we verify
NCT04945928
Safety and Feasibility of Surgery After Conversion Therapy for Locally Advanced and Advanced NSCLC
NA trial testing Surgery in Pulmonary Neoplasm in 30 participants. Participants enrolled and being followed up; not accepting new ones.
5 June 2024
Quick facts
| Lead sponsor | Ruijin Hospital |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 27 August 2021 |
| Primary completion | 5 June 2024 |
| Estimated completion | 5 June 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- Surgery
Conditions studied
- Pulmonary Neoplasm — all drugs for Pulmonary Neoplasm →
- Advanced Cancer — all drugs for Advanced Cancer →
- Locally Advanced Cancer — all drugs for Locally Advanced Cancer →
Sponsor
Ruijin Hospital
Who can join
18 and older, any sex, with Pulmonary Neoplasm or Advanced Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Lung cancer is one of the most common malignant tumors worldwide and the mortality ranks first in the world. In recent years, with the development of targeted therapy and immunotherapy, the overall survival of lung cancer patients has improved significantly. However, the inoperable advanced tumor remains the main reason for the poor prognosis of lung cancer. Thus, we aim to carry out this single-arm, prospective study to evaluate the safety and feasibility of surgery after conversion therapy for locally advanced and advanced non-small cell lung cancer.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Immunotherapy during the Immediate Perioperative Period: A Promising Approach against Metastatic Disease.
Sandbank E, Eckerling A, Margalit A, Sorski L, et al · · 2023 · cited 10× · PMID 37623021 · DOI 10.3390/curroncol30080540 -
Conversion Surgery After Induction Therapy for Initially Unresectable Stage III Non-small Cell Lung Cancer: A Proof-of-Concept Trial.
Yan Y, Han Y, Niu Z, Zhang X, et al · · 2026 · PMID 41880079 · DOI 10.1245/s10434-026-19461-z
Verify or expand the search:
- PubMed search for NCT04945928
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Pulmonary Neoplasm
Currently open trials in the same condition.
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Other Ruijin Hospital trials
Trials by the same sponsor.
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- NCT07511114 — A Study Comparing C Pola R-CHP+X With CR-CHOP in the Treatment of Previously Untreated DEL Under the Guidance of Genotyp · Phase 3 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04945928 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ruijin Hospital
- Last refreshed: 24 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04945928.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing