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NCT04945889
Sepsis in Geriatric Patients With Suspected Infection.
trial testing Quick Sequential Organ Failure Assessment (qSOFA) in Sepsis in 580 participants. Completed in 31 October 2019.
31 October 2019
Quick facts
| Lead sponsor | A.O.U. Città della Salute e della Scienza |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 580 |
| Start date | 1 April 2019 |
| Primary completion | 31 October 2019 |
| Estimated completion | 31 October 2019 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- Quick Sequential Organ Failure Assessment (qSOFA)
- Modified Early Warning Score (MEWS)
- National Early Warning Score (NEWS)
Conditions studied
- Sepsis — all drugs for Sepsis →
Sponsor
A.O.U. Città della Salute e della Scienza — full company profile →
Who can join
65 and older, any sex, with Sepsis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Sepsis is a complex clinical syndrome that has been defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is more frequent and severe in older subjects, at least in part because of delayed diagnosis and treatment due to low clinical suspicion and atypical manifestation. The Sepsis-III consensus proposed the easy to use bedside clinical score quick Sequential Organ Failure Assessment (qSOFA) to identify patients at risk for sepsis and death outside intensive care units. However, some Authors have disputed this recommendation, proposting the use of other more complex bedside tools such as the National and Modified Early Warning Scores (NEWS and MEWS, respectively) for the same purpose. Published studies on these scores included generally younger, selected subjects, not fully representative of the population at risk for sepsis. In the present study we aimed to evaluate the incidence of sepsis in older subjects with suspected infection in a geriatric acute ward setting, to determine and compare the accuracies of qSOFA, NEWS and MEWS to identify sepsis and to investigate factors associated with in-hospital mortality.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04945889
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other A.O.U. Città della Salute e della Scienza trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04945889 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by A.O.U. Città della Salute e della Scienza
- Last refreshed: 30 June 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04945889.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing