NCT04945655: PrevHPV

Impact of a School- and Primary Care-based Multicomponent Intervention on HPV Vaccination Acceptability

Completed NA Last updated 10 December 2025

What this trial tests

NA trial testing Adolescents and parents' education and motivation at school (component 1) in HPV Vaccine Acceptability in 30,739 participants. Completed in 30 April 2023.

Timeline

15 November 2021

Primary endpoint
30 June 2022

30 April 2023

Quick facts

Lead sponsor	Institut National de la Santé Et de la Recherche Médicale, France
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	factorial
Masking	none
Primary purpose	prevention
Enrollment	30,739
Start date	15 November 2021
Primary completion	30 June 2022
Estimated completion	30 April 2023
Sites	1 location across France

Drugs / interventions tested

• Adolescents and parents' education and motivation at school (component 1)
• General practitioners' training (component 2)
• Access to vaccination at school (component 3)

Conditions studied

• HPV Vaccine Acceptability — all drugs for HPV Vaccine Acceptability →

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France — full company profile →

Who can join

Eligibility, any sex, with HPV Vaccine Acceptability. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims at evaluating the effectiveness, efficiency and implementation of a multicomponent intervention (components being applied in combination or alone) on the acceptability of HPV vaccine among French adolescents (11-14 years old) through a cluster randomized controlled trial. The primary outcome to measure acceptability is vaccine coverage. The three components are: adolescents and parents' education and motivation at school (component 1); general practitioners' training (component 2); and access to vaccination at school (component 3). Ninety municipalities are included and randomized into six groups of 15 municipalities, according an incomplete factorial plan.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Impact of a school-based and primary care-based multicomponent intervention on HPV vaccination coverage among French adolescents: a cluster randomised controlled trial protocol (the PrevHPV study).
   Bocquier A, Michel M, Giraudeau B, Bonnay S, et al · · 2022 · cited 19× · PMID 35332045 · DOI 10.1136/bmjopen-2021-057943
2. Effectiveness of a School- and Primary Care-Based HPV Vaccination Intervention: The PrevHPV Cluster Randomized Trial.
   Thilly N, Michel M, Simon M, Bocquier A, et al · · 2024 · cited 18× · PMID 38780943 · DOI 10.1001/jamanetworkopen.2024.11938
3. Sociodemographic determinants of HPV vaccine awareness, uptake, and intention among parents of adolescents in France 2021-22.
   Rivera AF, Dussault JM, Oudin Doglioni D, Chyderiotis S, et al · · 2024 · cited 10× · PMID 39105306 · DOI 10.1080/21645515.2024.2381300
4. Implementation evaluation of a school- and primary care-based multicomponent intervention to improve HPV vaccine coverage: Results from the PrevHPV randomized controlled trial.
   Bocquier A, Simon M, Michel M, Bonnay S, et al · · 2025 · cited 1× · PMID 40834467 · DOI 10.1016/j.jiph.2025.102931
5. Process evaluation of a school-based vaccination intervention to improve HPV vaccine coverage: A mixed-method study embedded in the French PrevHPV cluster randomized controlled trial.
   Bocquier A, Cadoret S, Fall E, Bonnay S, et al · · 2026 · PMID 41412015 · DOI 10.1016/j.vaccine.2025.128122
6. Effect of a multicomponent HPV intervention on self-reported HPV vaccine uptake and intention among French adolescents and parents: results from the national, cluster-randomised PrevHPV trial.
   Dussault J, Gagneux-Brunon A, Le Duc-Banaszuk AS, Bruel S, et al · · 2025 · PMID 40761362 · DOI 10.1136/bmjph-2024-001007