NCT04944251 is a NA clinical trial of Regular Exercise in Multiple Sclerosis, sponsored by Ege University.

Who is sponsoring NCT04944251?

NCT04944251 is sponsored by Ege University.

What drugs are being tested in NCT04944251?

Interventions in NCT04944251: Regular Exercise.

What condition does NCT04944251 study?

NCT04944251 studies Multiple Sclerosis, Exercise Intervention, Neuro-Degenerative Disease.

Is NCT04944251 still recruiting?

NCT04944251 is currently completed. Last updated 29 June 2021.

Last reviewed 2021-06-29 · How we verify

NCT04944251

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Regular Exercise Improves Physical Capacity and Promotes Neurotrophins in Patients With Multiple Sclerosis

Completed NA Last updated 29 June 2021

What this trial tests

NA trial testing Regular Exercise in Multiple Sclerosis in 43 participants. Completed in 19 January 2020.

Timeline

1 April 2019

Primary endpoint
1 December 2019

19 January 2020

Quick facts

Lead sponsor	Ege University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	43
Start date	1 April 2019
Primary completion	1 December 2019
Estimated completion	19 January 2020
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

Regular Exercise

Conditions studied

Multiple Sclerosis — all drugs for Multiple Sclerosis →
Exercise Intervention — all drugs for Exercise Intervention →
Neuro-Degenerative Disease — all drugs for Neuro-Degenerative Disease →

Sponsor

Ege University

Who can join

Adults 18 to 55, any sex, with Multiple Sclerosis or Exercise Intervention. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

ABSTRACT Objective: The investigators aimed to determine the effect of regular exercise on aerobic capacity, strength values, and plasma levels of nerve growth factor (NGF) and Neurotrophin-3 (NT-3) in patients with multiple sclerosis (MS), and investigate its effects on MS symptoms including cognitive impairment, fatigue, balance disorders and quality of life. Methods: Forty-three relapsing-remitting MS (RRMS) patients with an EDSS score of 4 or less participated in the study. Participants were divided into 3 groups as aerobic exercise, strength exercise and control groups. The patients in the exercise groups had exercise programs 3 days a week, for 3 months. Aerobic capacity (maximum VO2 value), strength measurements and balance tests were done, and NGF and NT-3 plasma levels were analyzed in all participants at the beginning and end of the study. MSQoL54 quality of life, fatigue impact scale (FIS), Pittsburgh Sleep Quality Index (PSQI) and BICAMS scale were applied to evaluate cognitive functions.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Exercise Improves Physical Capacity, Cognition, Quality of Life and Promotes Neurotrophic Factors in Patients with Multiple Sclerosis.
Açık M, Şenışık S, Taşkıran D, Akşit T, et al · · 2023 · cited 2× · PMID 38077844 · DOI 10.29399/npa.28302

Verify or expand the search:

Other trials of Regular Exercise

Trials testing the same drug.

NCT06717828 — The Effects of Tai Chi on Metabolic Dysfunction-associated Fatty Liver Disease in Middle-Aged and Older Adults · NA · recruiting
NCT03782779 — Diaphragmatic Breathing Program In Older People · NA · completed

Other recruiting trials for Multiple Sclerosis

Currently open trials in the same condition.

NCT07507084 — The Effect of Internal- or External-Focused Exercise Training, Administered in Conjunction With a Cognitive Task, on Wal · NA · recruiting
NCT07524231 — Evaluation of the Effects of Laughter Yoga · NA · recruiting
NCT07489794 — URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS · recruiting
NCT07236684 — Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity · recruiting
NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting

Other Ege University trials

Trials by the same sponsor.

NCT07468227 — Effect of Helfer Skin Tap and Vibration on Pain and Fear in Children During Intramuscular Injection · NA · not yet recruiting
NCT07473050 — Virtual Reality-Based 'Health at My Feet' Program for Individuals With Type 2 Diabetes · NA · not yet recruiting
NCT06955338 — Music and VR Effects on Pain, Anxiety, and Fear During Oral Mucositis Care in Leukaemic Children · NA · not yet recruiting
NCT07344532 — Effect of Preoperative Abdominal Effleurage on Postoperative Constipation · NA · not yet recruiting
NCT07417748 — Kinesthetic Exercises on Adults · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04944251 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ege University
Last refreshed: 29 June 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04944251.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing