Who is sponsoring NCT04942106?

NCT04942106 is sponsored by Boston College.

What drugs are being tested in NCT04942106?

Interventions in NCT04942106: Arm 1 - Side-lying position followed by Supine position, Arm 2 - Supine position followed by Side-lying position.

What condition does NCT04942106 study?

NCT04942106 studies Feeding, Bottle, Infant, Premature, Diseases, Behavior, Infant.

Is NCT04942106 still recruiting?

NCT04942106 is currently completed. Last updated 12 July 2024.

Last reviewed 2024-07-12 · How we verify

NCT04942106

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Biobehavioral Efficacy of the Semi-Elevated Side-Lying Position

Completed NA Last updated 12 July 2024

What this trial tests

NA trial testing Arm 1 - Side-lying position followed by Supine position in Feeding, Bottle in 60 participants. Completed in 31 May 2024.

Timeline

10 March 2022

Primary endpoint
31 May 2024

31 May 2024

Quick facts

Lead sponsor	Boston College
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	supportive care
Enrollment	60
Start date	10 March 2022
Primary completion	31 May 2024
Estimated completion	31 May 2024
Sites	1 location across United States

Drugs / interventions tested

Arm 1 - Side-lying position followed by Supine position
Arm 2 - Supine position followed by Side-lying position

Conditions studied

Feeding, Bottle — all drugs for Feeding, Bottle →
Infant, Premature, Diseases — all drugs for Infant, Premature, Diseases →
Behavior, Infant — all drugs for Behavior, Infant →

Sponsor

Boston College

Who can join

Under 2 Months, any sex, with Feeding, Bottle or Infant, Premature, Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of the proposed research is to conduct a within-subject cross-over trial that will compare the efficacy of the two bottle-feeding positions on physiologic and behavioral responses of preterm infants prior to, during, and after feeding. As an exploratory aim, the investigators will also identify potential infant characteristics associated with the intervention response by evaluating infant sex, maturity level, and/or comorbidity. The two bottle-feeding positions will be the semi-elevated side-lying position (hereafter referred to as side-lying position) and the semi-elevated supine position (hereafter referred to as supine position), which is the traditional feeding position when preterm infants are bottle-fed. The investigators hypothesize that compared to the supine position, the side-lying position will be associated with greater physiologic stability in heart rate, respiratory rate, oxygen saturation, and/or autonomic nervous system regulation during and after feeding. The investigators also hypothesize that compared to the supine position, the side-lying position will be associated with more mature patterns of suck-breathe coordination and/or greater feeding skills.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Biobehavioral Efficacy of the Elevated Side-Lying Position for Feeding Preterm Infants: Study Protocol.
Park J, Thoyre S, Smallcomb J, Mcternan M, et al · · 2025 · cited 1× · PMID 39231735 · DOI 10.1111/jan.16444

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04942106 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Boston College
Last refreshed: 12 July 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04942106.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing